The Andrew lab studies molecular diagnostics for bladder and lung cancers, toxic metal carcinogenesis, genetic susceptibility, gene-environment interactions.
Dr. Galton studies the roles of the iodothyronine deiodinases in the regulation of intracellular thyroid hormone levels and thyroid hormone action during development and in adult mammals. Studies use mice made deficient in the either or both the types 1 and 2 iodothyronine deiodinase.
Dr. Lewis is interested in the study of novel antineoplastic agents and their pharmacokinetics and pharmacodynamics when first given to cancer patients (i.e. first time in man, Phase I studies of new drugs in cancer patients); mechanisms of toxicity of nucleoside analogues and antineoplastic agents to the mitochondrion and ways of ameliorating this toxicity.
Dr. Maue is interested in cellular and molecular mechanisms underlying neuronal development in the CNS, particularly as related to neurodegenerative diseases; neurotrophin and growth factor actions; regulation of neuronal ion channels and genes; molecular biology; electrophysiology.
The Spaller lab is interested in the discovery and development of cellular probes and therapeutic agents targeting protein-protein interactions; chemical biology; peptide and organic small molecule design and synthesis; chemical libraries for biochemical and cell-based screening; protein biochemistry and biophysical analysis of protein-ligand interactions.
The Wishart lab studies Functional and Structual Magnetic Resonance Imaging: Neurobiological basis of heterogeneity in multiple sclerosis. A hallmark of multiple sclerosis (MS) is its interindividual heterogeneity. Dr. Wishart's research program uses structural and functional MRI and genotyping to discover neurobiological mechanisms of heterogeneity in symptomatology, course and treatment response in MS, with the ultimate aim of improving early, individualized characterization and treatment of the disease.