Dr. Bosco's laboratory has two major interests: 1. Chromosome, chromatin dynamics and gene regulation. 2. Learning, memory, aging and mechanisms of trans-generational inheritance.
We are interested in understanding the molecular basis of how nuclear architecture, chromosome and chromatin structure and how changes in these structures impact gene expression. We are also interested in how changes in structure influence genetic and epigenetic inheritance of physical traits.
The Bosco lab is also interested in understanding basic mechanisms of chromosome and nuclear architecture that may be important for aging biology. There are numerous human diseases and pathologies (for example cancer, progeria, muscular dystrophy and others) that are either associated with or caused by mutations in nuclear and chromosomal structural proteins. We seek to understand how nuclear lamin and nuclear pore complex proteins cooperate with condensins to maintain 3-dimensional spatial organization of genomes, and how loss of specific spatial organizational states contributes to human disease and normal human aging.