Neuroscience Laboratories

Bosco Lab

 

 Dr. Bosco's laboratory has two major interests:  1. Chromosome, chromatin dynamics and gene regulation.  2. Learning, memory, aging and mechanisms of trans-generational inheritance.

We are interested in understanding the molecular basis of how nuclear architecture, chromosome and chromatin structure and how changes in these structures impact gene expression. We are also interested in how changes in structure influence genetic and epigenetic inheritance of physical traits.

The Bosco lab is also interested in understanding basic mechanisms of chromosome and nuclear architecture that may be important for aging biology. There are numerous human diseases and pathologies (for example cancer, progeria, muscular dystrophy and others) that are either associated with or caused by mutations in nuclear and chromosomal structural proteins. We seek to understand how nuclear lamin and nuclear pore complex proteins cooperate with condensins to maintain 3-dimensional spatial organization of genomes, and how loss of specific spatial organizational states contributes to human disease and normal human aging. 

Bucci Lab

Dr. Bucci's laboratory studies the behavioral and neurobiological factors that regulate learning and memory. By combining classical conditioning procedures with biochemical, chemogenetic, pharmacological and neuroanatomical techniques, the lab studies topics such as functional interactions between cortical-hippocampal systems, mechanisms underlying attention and learning, and the development of learning and memory processes.  One goal of this research is to further our understanding of the basic mechanisms of information processing in the brain. A second goal is to relate these findings to the biological basis of cognitive dysfunction and mental illness in humans.

Doucette Lab

The Doucette laboratory uses pre-clinical models to study the neurobiology and treatment development for disorders of appetitive behavior (e.g. substance use, eating disorders and obesity). Current methodologies include a combination of awake-behaving electrophysiology and focal neuromodulation using deep brain stimulation. 

Gaur Lab

Dr. Gaur's laboratory research can be broadly divided into the following three areas:

Basic Research: Understanding the critical contribution of microRNAs and their targets to various pathologies of the nervous system.

Translational Research: Running clinical trials to establish the role of microRNAs as diagnostic and prognostic biomarkers and therapeutic agents in gliomas as well as biomarkers of treatment efficacy and toxicity in glioma patients.

Biomedical Engineering: Developing innovative, in vivo wireless, nano scale devices for early detection of disease as well as regulated and targeted drug delivery.

Gilli Lab

 

Dr. Gilli's lab is interested in understanding the neuroimmunology of Multiple Sclerosis (MS) and its rodent models. Particularly, we are investigating the cellular and molecular pathways that contribute to neuroinflammation and central nervous system (CNS)-related tissue damage, aiming at understanding how inflammation contributes to neurodegeneration and disability progression in MS. The overall intention of this work is to identify new therapeutic targets or strategies that will improve our ability to manage progressive MS as well as other neurodegenerative diseases.

Granger Lab

The Granger lab studies computational and cognitive neuroscience: analyses of how our brains operate to perceive, comprehend and manipulate their environments, as well as how they fail in certain conditions. We strive both to understand and analyze brain circuits, and, where possible, to construct equivalent circuits -- ranging from fMRI neuroimaging studies to robotics. Throughout these studies, real-world applications are developed as our understanding deepens. 

A. Green Lab

Dr. Green's lab uses animal and humans to study the actions of antipsychotic drugs, as related to their use in patients with schizophrenia and substance use disorders. The work focuses on brain reward circuitry, and manipulation of this circuitry by antipsychotic drugs and other psychoactive agents.

Gulledge Lab

Dr. Gulledge's laboratory uses electrophysiological and imaging methods to record activity in individual neurons in cortical slices. Because there are many diverse classes of neurons in the cortex, and because these transmitters often have five or more receptor subtypes linked to different signaling pathways, a single transmitter can have many effects on cellular activity. For instance, acetylcholine can be both excitatory and/or inhibitory, depending upon the type of neuron and the duration of exposure to the transmitter. Revealing the interaction of these multiple signaling mechanisms is a core focus of the laboratory.

Havrda Lab

Dr. Havrda's laboratory studies molecular events contributing to the initiation and progression of Parkinson's disease. Investigating the neuroinflammatory activities of disease associated environmental toxins using molecular, cellular and organismal approaches.

Hill Lab

 

The Hill laboratory studies the multicellular interactions between neurons and glia in the brain with a primary focus on the development, plasticity, and regeneration of myelinating oligodendrocytes. Techniques include high-resolution optical imaging in combination with molecular labels, genetic manipulation, and sensors of cellular physiology.

Holtzheimer Lab

Dr. Holtzheimer laboratory focuses on neurobiology and treatment of mood disorders, primarily treatment-resistant depression. Current methodologies include functional and structural neuroimaging and focal neuromodulation techniques such as transcranial magnetic stimulation and deep brain stimulation.

Hong Lab

Dr. Hong's lab is studying the effects of conditional PTEN knockout in the mouse peripheral nervous system on sciatic nerve regeneration, in order to assess the feasibility of regulating PTEN expression to aid in recovery from peripheral nerve injuries in patients.

Hoppa Lab

Dr. Hoppa's laboratory concentrates on the regulation of ion channels, small molecular pores in the cell membrane that establish resting membrane potential, shape action potentials and regulate the influx of calcium critical to initiating exocytosis. Because the neuron is so morphologically diverse, we concentrate on using light to quantitatively measure physiological outputs from neurons using optogenetic indicators in combinations with genetic and biochemical approaches. 

Jobst Lab

Dr. Jobst's laboratory studies the neurophysiology of cognitive deficit in patients with epilepsy. Patients are implanted with intracranial electrodes for epilepsy surgery and cognitive tasks are performed while single neuron activity is recorded from the human brain. Also researches brain stimulation for the treatment of epilepsy and memory deficits.

Luikart Lab

Dr. Luikart's laboratory focuses on performing stable, precise, and well characterized genetic manipulations in mice and then evaluating the functional impact of the genetic manipulation using whole-cell electrophysiology and imaging.  It employs a variety of in vitro systems to gain molecular insight into the physiologically relevant phenotypes that are uncovered in vivo.

Nautiyal Lab

Our lab studies how the brain regulates behaviors like impulsivity and aggression, with a focus on the systems-level mechanisms through which serotonin modulates the underlying neural circuits. We use genetic and viral manipulations of serotonin signaling in mouse models, and measure the effects on behavior and also concurrent cellular activity using in vivo calcium imaging. 

Pachner Lab

Our laboratory is focused on translational research in Multiple Sclerosis (MS), a chronic inflammatory, disabling disease of the CNS. We are working on both patients with MS and experimental models of MS in rodents to develop improved biomarkers and therapies. 

Robertson Lab

The Robertson lab seeks to understand the marriage of sensory and cognitive signals in the human brain.  This intersection is particularly relevant to understanding psychiatric conditions such as autism, in which different patterns of higher-order cognition are reflected in how people engage with the sensory world.  

By studying how people see the world, we can learn about the structure of cognition and, in return, learn how different patterns of thought shape our experience of the world around us.

Smith Lab

The Smith Lab conducts research on how the brain works to generate reward, motivation, actions, and habits. Our work incorporates techniques to record neural activity, modulate neuronal activity at sub-second timescales, study brain chemistry, and map brain connections. The research is relevant to understanding disorders of reward and action, like addiction, Parkinson’s disease, and obsessive-compulsive spectrum disorders.

Taube Lab

The Taube lab studies neurobiology of spatial orientation and navigation, learning and memory. Understanding 1) the neurobiological basis of spatial cognition and navigation, and 2) the neurobiological mechanisms underlying learning and memory. We use single cell chronic unit recording techniques in rodents to correlate the activity of neurons with the animal's behavior. 

van der Meer Lab

The van der Meer lab studies the interplay between learning, memory, and prediction in rodents performing decision tasks. We record and decode the activity of many neurons simultaneously during behavior to reveal the neural representations and transformations that underlie cognitive processes such as deliberation, inference, and planning. Through a combination of neurobiological and computational approaches, we seek a fundamental understanding of these processes at the level of neural circuits, within and across interacting brain areas such as the hippocampus, striatum, and frontal cortex. We believe that in the long term, this understanding can support sustained innovation in the prevention and treatment of disorders such as addiction and obsessive-compulsive disorder.