Alison Paquette

Research Scientist, Institute of Systems Biology, Seattle, Washington

I am currently a Research Scientist at the Institute for Systems Biology (ISB) in Seattle WA, where I use data driven approaches to better understand the causes and underlying pathology of pregnancy related complications including preterm birth and preeclampsia.  These pregnancy complications are very common in the United States, and lead to long term health complications for both mother and Infant.  My objective for my post-doctoral fellowship at the ISB is to leverage the experience with placental physiology and pregnancy outcomes I gained during my doctoral studies with the computational resources of the institute of systems biology to learn how to perform multiscale analysis of molecular data in order to obtain a better understanding of the complex molecular changes occurring over the course of pregnancy.  This integrated approach will yield new insights into clinical and non clinical interventions which will predict and prevent preterm birth and other pregnancy complications.

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Education

PhD, '15, Program in Experimental and Molecular Medicine

Selected Publications

  • Lesseur C, Armstrong DA, Paquette AG, Koestler DC, Padbury JF, Marsit CJ. Lesseur, C. (2013). Tissue-specific Leptin promoter DNA methylation is associated with maternal and infant perinatal factors. Molecular and Cellular Endocrinology, DOI: doi: 10.1016/j.mce.2013.07.024

  •  Paquette AG, Lesseur C, Armstrong DA, Koestler DC, Appleton AA, Lester BM, Marsit CJ. (2013). Placental HTR2A methylation is associated with infant neurobehavioral outcomes. Epigenetics, DOI: 10.4161/epi.25358

     

  • Lesseur C, Armstrong DA, Murphy MA, Appleton AA, Koestler DC, Paquette AG, Lester BM, Marsit CJ. (2014) Sex-specific associations between placental leptin promoter DNA methylation and infant neurobehavior. Psychoneuroendocrinology, DOI: 10.1016/j.psyneuen.2013.10.012

  • Lesseur C, Paquette AG, Marsit CJ. (2014). Epigenetic regulation of infant neurobehavioral outcomes. Medical Epigenetics, DOI: 10.1159/000361026

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Awards

Dartmouth Graduate Student Travel Award, 2013

Dartmouth Graduate Student Counsel Travel Grant, 2014