Amanda Balboni Iniguez

Scientist II, Cancer Immunotherapy at bluebird bio

I graduated from the PEMM program in 2014 and am currently a Scientist (Cancer Immunotherapy) at bluebird bio. During my graduate training, the PEMM program gave me tremendous support and guidance which helped shape me into a well-trained molecular and cellular biologist.  I started my postdoc fully equipped with the skills necessary to continue a career as an academic scientist. My postdoctoral studies are aimed at identifying and characterizing genetic vulnerabilities of pediatric Ewing sarcoma and neuroblastoma with the ultimate goal of developing rational targeted therapeutics for these diseases. My research projects integrate several functional genomics and chemical biology approaches to systematically identify tumor vulnerabilities, synthetic lethal interactions, and mechanisms of therapeutic resistance in these diseases.

Education

  • PhD, '14, Program in Experimental and Molecular Medicine, Dartmouth College
  • BS, '09, Boston College

Selected Publications

  • Balboni A, Cherukuri P, Ung M, DeCastro AJ, Cheng C, DiRenzo J. P53 and deltaNp63alpha co-regulate transcriptional responses to TGFBeta and BMP signals in the Mammary Epithelium. Mol Cancer Res. 2015 Feb 19; PubMed PMID: 25700283.

  • DeCastro AJ, Cherukuri P, Balboni A, DiRenzo J. DeltaNp63alpha transcriptionally activates chemokine receptor 4 (CXCR4) expression to regulate breast cancer stem cell activity and chemotaxis. Mol Cancer Ther. 2015 Jan; 14:225-35.

  • Dunphy KA, Seo JH, Kim D, Roberts AL, Tao L, DiRenzo J, Balboni A, Crisi GM, Hagen MJ, Chandrasekaran T, Gauger KJ, Smith-Schneider SW, Jerry DJ.  Oncogenic transformation of mammary epithelial cells by TGF-beta independent of mammary stem cell regulation. Cancer Cell Int. 2013 Jul 25;13:74.

  • Decastro AJ, Dunphy KA, Hutchinson J, Balboni A, Cherukuri P, Jerry DJ, DiRenzo J. MiR203 mediates subversion of stem cell properties during mammary epithelial differentiation via repression of DeltaNP63alpha and promotes mesenchymal-to-epithelial transition. Cell Death Dis. 2013 Feb 28;4: e514.

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Awards

Damon Runyon Sohn Pediatric Fellowship Award, 2015-Present              

The Damon Runyon-Jake Wetchler Award for Pediatric Innovation, 2017

DFCI Postdoctoral and Graduate Association Travel Award, 2016

Albert J. Ryan Predoctoral Fellowship, 2012-2014