The Lau Laboratory investigates pathways that can be modulated to prevent malignant transformation or treat cancers that arise in patients with cancer predisposition syndromes. One focus of the lab is to study premalignant and malignant tissue from patients with DNA damage repair defects (e.g. Fanconi Anemia) and determine whether the mutations in these patients result in new protein coding sequences, called neoantigens, which can be recognized as "foreign" by the patient's immune system. Certain neoantigen profiles can predict response to therapies that work by unleashing the patient's own immune system to attack their tumor (immunotherapies). We are using gene editing as well as mouse models to study these cancer predisposition syndromes and how their tumors respond to immunotherapies.
Lau BW, Huh K, Madero-Marroquin R, De Marchi F, Lim Y, Wang Q, Lobo F, Marchionni L, Smith DB, DeZern A, Levis MJ, Aplan PD, Matsui W, Gondek LP. Hedgehog/GLI1 activation leads to leukemic transformation of myelodysplastic syndrome in vivo and GLI1 inhibition results in antitumor activity. Oncogene. 2019 Jan;38(5):687-698. doi: 10.1038/s41388-018-0431-9. Epub 2018 Aug 31. PubMed PMID: 30171262.
Candoni A, De Marchi F, Zannier ME, Lazzarotto D, Filì C, Dubbini MV, Rabassi N, Toffoletti E, Lau BW, Fanin R. High prognostic value of pre-allogeneic stem cell transplantation minimal residual disease detection by WT1 gene expression in AML transplanted in cytologic complete remission. Leuk Res. 2017 Dec;63:22-27. doi: 10.1016/j.leukres.2017.10.010. Epub 2017 Oct 27. PubMed PMID: 29096332.
De Marchi F, Candoni A, Zannier ME, Haley L, Lau BW, Fanin R. Concomitant monitoring of WT1 and FLT3-ITD expression in FLT3-ITD acute myeloid leukemia patients: which should we trust as a minimal residual disease marker?. Am J Hematol. 2017 May;92(5):E72-E74. doi: 10.1002/ajh.24686. Epub 2017 Mar 22. PubMed PMID: 28211167.
Lau B, Khazanie U, Rowe E, Fauman K. How a Drug Shortage Contributed to a Medication Error Leading to Baclofen Toxicity in an Infant. J Pediatr Pharmacol Ther. 2016 Nov-Dec;21(6):527-529. doi: 10.5863/1551-6776-21.6.527. PubMed PMID: 28018156.