Kevin Johnson

Post-Doctoral Associate, The Jackson Laboratory for Genomic Medicine

 I am currently a postdoctoral research fellow at The Jackson Laboratory for Genomic Medicine in Farmington, CT. I received an American Cancer Society postdoctoral fellowship to investigate the defects in the cellular machinery of glioma, a type of adult brain tumor. One of the distorted molecular features of gliomas is faulty epigenetic regulation. [Broadly, epigenetics are those modifications to DNA that dictate whether genes are turned on and off.] I am particularly interested in how the glioma epigenome contributes to disease progression by studying both the primary tumor and the recurrent tumor at the single cell level. This will yield unprecedented knowledge about the evolutionary course of individual cells within a brain tumor, and provide insight into potential treatment options for cancer patients.

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Education

PhD, '16, Program in Experimental and Molecular Medicine, Dartmouth College

Selected Publications

  • Johnson KC, Houseman EA, King JE, Christensen BC. DNA methylation differences at regulatory elements are associated with the cancer risk factor age in normal breast tissue. Breast Cancer Research. 2017. PMCID: PMC5504720.

  • Johnson KC, Houseman EA, King JE, von Herrmann KM, Fadul CE, Christensen BC. 5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients. Nat Commun. 2016 Nov 25;7:13177. PubMed PMID: 27886174; PubMed Central PMCID: PMC5133638.*

    *Featured on NIH Director’s Blog and Genome Web

  • O'Sullivan DE*, Johnson KC*, Skinner L, Koestler DC, Christensen BC. Epigenetic and genetic burden measures are associated with tumor characteristics in invasive breast carcinoma. Epigenetics. 2016. *Co-first author

  • Kresoja-Rakic J, Kapaklikaya E, Ziltener G, Dalcher D, Santoro R, Christensen BC, Johnson KC, Schwaller B, Weder W, Stahel RA, Felley-Bosco E. Identification of cis- and trans-acting elements regulating calretinin expression in mesothelioma cells. Oncotarget. 2016.

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Awards

Dartmouth Cancer Epidemiology Program Travel Award, 2016

Albert J. Ryan Predoctoral Fellow, 2014-15

Dartmouth Integrative Biology Symposium Poster Winner, 2015

Neukom Institute at Dartmouth Travel Grant, 2015

Neukom Institute at Dartmouth Travel Grant, 2014

Best Journal Club Presentation, MPTT/CBMT seminar series, 2013