I am a postdoctoral fellow in the Epigenetics and Molecular Carcinogenesis Department at MD Anderson Cancer Center. I am currently working on investigating a histone acetyltransferase (HAT) protein, GCN5, which is part of the transcriptional activator complex SAGA. GCN5 has found to be upregulated in certain cancer-types in comparison to normal tissues. My project involves investigating the role of GCN5 in lung cancer formation and progression to determine whether this enzyme can be inhibited as a new therapy for lung cancer.
Hu S, Lu Y, Orr B, Godek K, Mustachio LM, Kawakami M, Sekula D, Compton DA, Freemantle S, Dmitrovsky E. Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown. Mol Cancer Ther. 2015;14:2576-85.
Hu S, Danilov AV, Godek K, Orr B, Tafe LJ, Rodriguez-Canales J, Behrens C, Mino B, Moran CA, Memoli VA, Mustachio LM, Galimberti F, Ravi S, DeCastro A, Lu Y, Sekula D, Andrew AS, Wistuba II, Freemantle S, Compton DA, Dmitrovsky E. CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110. Cancer Res. 2015;75:2029-38.
Gui JG, Mustachio LM, Su DM, Craig RW. Thymus size and age-related thymic involution: early programming, sexual dimorphism, and stroma. Aging and Disease 2012; 3:280-90.
Dartmouth Graduate Student Travel Award, 2014