The Hayden Lab studies Cell Signaling in Inflammation, Autoimmunity, and Cancer;
Dysregulation of the immune response is a hallmark of a variety of disease states. Unchecked innate and adaptive immunity can lead to chronic inflammation or autoimmunity, while compromised immune responses facilitate infection and tumorigenesis. The NF-kappaB signaling pathway is an essential mediator of communication amongst cells of the immune system and between the immune system and non-immune host cells. Dysregulation of NF-kappaB in a variety of diseases, including autoimmunity, inflammation, and cancer, is well described. In the Hayden lab, we are interested in elucidating the mechanisms leading to NF-kappaB dysregulation and are working to identify more selective approaches to manipulating the NF-kappaB pathway for in order to develop novel immunomodulatory therapies.