Periannan Kuppusamy

  • Professor of Radiology

  • Professor of Medicine

Dr. Kuppusamy’s research expertise includes detection and imaging of oxygen free radicals; myocardial ischemia-reperfusion injury; stem-cell therapy for cardiac repair; ROS pathophysiology in vascular remodeling; tumor physiology, oxygenation, and drug-resistance; small-molecule therapeutics for heart disease and cancer; technology development for noninvasive measurement of tissue oxygen levels (oximetry); molecular probes for free radical biology and medicine; EPR spectroscopy, imaging software, and instrumentation.

+ View more


601 Rubin
HB 7785


  • 1987-90 Cardiovascular Fellowship - Johns Hopkins University
  • 1986-87 Fogarty Fellow, National Institutes of Health
  • 1980-85 PhD - Indian Institute of Technology (Chennai)
  • 1975-77 MSc - University of Madras
  • 1972-75 BSc - University of Madras

Selected Publications

  • Madan E, Pelham CJ, Nagane M, Parker TM, Canas-Marques R, Fazio K, Shaik K, Yuan Y, Henriques V, Galzerano A, Yamashita T, Pinto MAF, Palma AM, Camacho D, Vieira A, Soldini D, Nakshatri H, Post SR, Rhiner C, Yamashita H, Accardi D, Hansen LA, Carvalho C, Beltran AL, Kuppusamy P, Gogna R, Moreno E. Flower isoforms promote competitive growth in cancer. Nature. 2019 Jul 24; doi: 10.1038/s41586-019-1429-3. Epub 2019 Jul 24. PMID: 31341286

  • Kmiec MM, Tse D, Mast JM, Ahmad R, Kuppusamy P. Implantable microchip containing oxygen-sensing paramagnetic crystals for long-term, repeated, and multisite in vivo oximetry. Biomedical Microdevices. 2019 Jul 8;21(3):71. doi: 10.1007/s10544-019-0421-x. Epub 2019 Jul 8. PMID: 31286244

  • Mast JM, Tse D, Shee K, Lakshmi Kuppusamy M, Kmiec MM, Kalai T, Kuppusamy P. Diarylidenylpiperidones, H-4073 and HO-3867, Induce G2/M Cell-Cycle Arrest, Apoptosis and Inhibit STAT3 Phosphorylation in Human Pancreatic Cancer Cells. Cell Biochem Biophys. 2019 Jun;77(2):109-119. doi: 10.1007/s12013-019-00873-6. Epub 2019 May 14. PMID: 31089934

  • Polacco MA, Hou H, Kuppusamy P, Chen EY. Measuring Flap Oxygen Using Electron Paramagnetic Resonance Oximetry. Laryngoscope. 2019 Apr 29; doi: 10.1002/lary.28043. Epub 2019 Apr 29. PMID: 31034638

+ View more