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In the lab of James Walker I am implementing a multi-pronged approach combining transcriptomics and proteomics to identify alterations in signaling pathways attributed to loss of neurofibromin, which plays a causative role in the genetic condition Neurofibromatosis type 1 (NF1). This work is closely related to the work I carried out as a graduate student, and it was due to the support I received in my graduate work that I was able to travel to the NF Conference in Paris in 2018 and met my post-doctoral mentor. The ultimate goal of this work is to identify novel targetable pathways and biomarkers for NF1, as well as a greater understanding of the genotype-phenotype correlations between neurofibromin loss and NF1 symptoms.
Allaway RJ, Wood MD, Downey SL, Bouley SJ, Traphagan NA, Wells JD, Batra J, Melancon SN, Ringelberg C, Seibel W, Ratner N, and Sanchez Y. Exploiting mitochondrial and metabolic homeostasis as a vulnerability in NF1 deficient cells. Oncotarget. 2017 July 18.
Way GP, Allaway RJ, Bouley SJ, Fadul CE, Sanchez Y, and Greene CS. A machine learning classifier trained on cancer transcriptomes detects NF1 inactivation signal in glioblastoma. BMC Genomics. 2017 Feb 6.
Hosford SR, Dillon LM, Bouley SJ, Rosati R, Yang W, Chen VS, Demidenko E, Morra RP, Miller TW. Combined inhibition of both p110α and p110β isoforms of phosphatidylinositol 3-kinase is required for sustained therapeutic effect in PTEN-deficient, ER+ breast cancer. Clin Cancer Res. 2016 Nov 30.
Allaway RJ, Fischer DA, de Abreu FB, Gardner TB, Gordon SR, Barth RJ, Colacchio TA, Wood M, Kacsoh BZ, Bouley SJ, Cui J, Hamilton J, Choi JA, Lange JT, Peterson JD, Padmanabhan V, Tomlinson CR, Tsongalis GJ, Suriawinata AA, Greene CS, Sanchez Y, Smith KD. Fine-needle biopsy patient-derived xenografts from early stage pancreatic cancer and patient-matched metastatic-PDX models for testing targeted agents. Oncotarget. 2016 Feb 25.
Molecular Therapeutics of Cancer Research Conference, Provo, UT. July 2018
The science of a Fulbright - Assumption College Annual Fulbright Recruitment Dinner. Worcester, MA. October 2017.
NF Conference. Washington, D.C. June 2017.
Molecular Therapeutics of Cancer Research Conference. Burlington, VT. July 2017.
Molecular Therapeutics of Cancer Research Conference. Seattle, WA. July 2016.
NCCC Travel Award, Norris Cotton Cancer Center, 2018
Albert J. Ryan Foundation Fellowship, 2017
NCCC Scientific Retreat Abstract Winner, Norris Cotton Cancer Center 2017
MTCRC Top Poster Presenter, Cancer Molecular Therapeutics Research Association 2017
GSC Conference Travel Grant, Dartmouth Graduate Student Counsel 2017
Outstanding Graduate Student Teacher, Dartmouth Center for the Advancement of Learning (DCAL) 2017
Young Investigator Award, Children’s Tumor Foundation 2016
OTHER NOTES
2012-2013 Fulbright Research Student (Deferred Dartmouth acceptance by 1 year to accept)
PATENTS
1) Sanchez, Y. Allaway, R. Bouley, S. Wood, M. “Vinylogous thioester compounds and methods of use.” United States Patent
Application US 2017/0152262 A1, September 30, 2016.
2) Sanchez, Y. Allaway, R. Bouley, S. Wood, M. “Vinylogous thioester compounds and methods of use.” WIPO Patent Application
WO/2017/059303, September 30, 2016.
Mentoring: Since joining the Sanchez Lab Stephanie has mentored 7 high school students, 22 undergraduate students (including 4 honors thesis students), and 5 graduate rotation students.
Teaching Experience: PEMM261 Coordinator, Fall 2018