Karl Biggs

Kettenbach and Havrda labs

Karl earned his Bachelors of Science in Neuroscience from UCLA. His research in the Kettenbach and Havrda labs is focused on the mechanisms of microglial response to misfolded protein aggregates and pesticides, specifically looking at endolysosomal dynamics and extracellular vesicle release . He primarily uses mass spectrometry based techniques coupled with biochemical assays and microscopy to investigate these mechanisms. He is a recipient of the Albert J. Ryan Fellowship. Outside of the lab Karl takes full advantage of everything New Hampshire has to offer, he enjoys backcountry skiing in the winter and trail running and backpacking in the summer. In his down time he likes to read and cook.

Contact

HB Hinman Box 7937

Selected Publications

  • Anderson FL, Biggs KE, Rankin BE, Havrda MC. NLRP3 inflammasome in neurodegenerative disease. Translational Research.  2023 Feb;252:21-33. doi: 10.1016/j.trsl.2022.08.006.

    Herrera-Vaquero M, Bouquio D, Kallab M, Biggs K, Nair G, Ochoa J, Heras-Garvin A, Heid C, Hadrovic I, Poewe W, Wenning GK, Klärner FG, Schrader T, Bitan G, Stefanova N. The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy. Biochim Biophys Acta Mol Basis Dis. 2019 Nov 1;1865(11):165513. doi: 10.1016/j.bbadis.2019.07.007.