Junghoon Lee

Chang lab

Junghoon receive both his B.S. and master's degree in Biology from Gwangju Institute of Science and Technology (GIST), Korea. He is working in the lab of Ta Yuan Chang in the Biochemistry and Cell Biology (BCB) department. He studies the cholesterol metabolism enzyme, ACAT1, as a therapeutic target for Niemann-Pick Type C (NPC) disease. He focuses on how ACAT1 inhibitors and AAV-driven ACAT1 blockade can ameliorate the pathologies in a NPC disease mouse model. Junghoon likes to go hiking, kayaking, and spend time with friends outdoors. 

Contact

Junghoon.Lee.GR@dartmouth.edu
HB Hinman Box 7200

Selected Publications

  • Ahreum Kwon, Gwi Bin Lee, Taein Park, Junghoon Lee, Panseon Ko, Eunae You, Jin Hee Ahn, Soo Hyun Eom, Sangmyung Rhee*, and Woo Keun Song*.Potent Small-Molecule Inhibitors Targeting Acetylated Microtubules as Anticancer Agents Against Triple-Negative Breast Cancer, Biomedicines, 2020 Sep; 8(9): 338., PMID: 32917017

    Yeong-Jin Kim, So Hee Kim, Yega Park, Jiyu Park, Junghoon Lee, Byeong C Kim, Woo Keun Song. miR-16-5p is upregulated by amyloid β deposition in Alzheimer's disease models and induces neuronal cell apoptosis through direct targeting and suppression of BCL-2, Exp Gerontol. 2020 Jul 15;136:110954., PMID: 32320719