Biochemistry Faculty

AMANDA A. AMODEO, Ph.D.

Assistant Professor of Biological Sciences

Office:  TBD

Phone:  603-646-9926

My lab seeks to uncover how cell size, zygotic genome activation, chromatin regulation, and the cell cycle come together to regulate early development in the Drosophila embryo. We use a combination of quantitative imaging, cell biology, genetics, genomics, biochemistry, and mathematical modeling to answer questions about how cells sense fundamental biological properties such as their size and developmental stage.

Website / Email / PubMed Articles

Prachee Avasthi, Ph.D.

Associate Professor of Biochemistry and Cell Biology

Office:  Vail 409A

Phone:  TBD

We are a fundamental cell biology lab using genetics, bioche­mistry, chemical biology, microscopy, and quantitative image analysis to probe how signaling and trafficking coordinate to build higher order cytoskeletal structures. We use the simplest and most powerful model system appropriate for our studies, a yeast-like alga Chlamydomonas reinhardtii,to study a conserved microtubule-based sensory organelle, the cilium. Defects in cilia, which are found on nearly all human cells, can cause blindness, kidney disease, diabetes, cancer, and other disorders.  We also study organization and regulation of the actin cytoskeleton, which we previously found has a major role in ciliary assembly. Lab projects span a wide array of topics including cytoskeletal dynamics, intracellular trafficking, and signal-dependent organelle regulation.

Website / Email / PubMed Articles /

Charles K. Barlowe, Ph.D.

James C. Chilcott 1920 Professor and Chair of Biochemistry and Cell Biology

Office: 414 Remsen

Phone: 603-650-6516


My research group investigates intracellular trafficking and we seek to understand the molecular mechanisms that control protein transport and quality control in the early secretory pathway. We use a multidisciplinary approach that includes biochemistry, molecular genetics, proteomics and microscopy in model systems.

Website | Email | PubMed Articles

 | Geisel Profile

Magdalena Bezanilla, Ph.D.

Ernest Everett Just 1907 Professor of Biological Sciences

Office: LSC 334

Phone: 603-646-2314


My research aims to understand how molecules within cells impart geometric information ultimately leading to cell shape determination. Research in my lab seeks to identify molecules within the cell that control cellular patterning. We are particularly interested in the role of regulators of the cytoskeleton and membrane trafficking and have pioneered the use of the moss Physcomitrella patens. Using the unusually rapid transgenic capabilities of moss, we are pursuing novel approaches to dissect the molecular mechanisms underlying plant cell shape.

Website | Email | PubMed Articles | Faculty Profile

T.Y. Chang, Ph.D.

Professor of Biochemistry and Cell Biology

Office: 304 Vail

Phone: 603-650-1622


The enzyme acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) is a membrane bound protein located at the endoplasmic reticulum. It plays important roles in health and in diseases. Our laboratory identified the ACAT1 gene. We are conducting structure-function analysis of ACAT1 in vitro, and taking mouse genetic approaches to determine the pathophysiological role of ACAT1 in Alzheimer's disease, in atherosclerosis, and in diet-induced obesity.

Website | Email | PubMed Articles

 | Geisel Profile

Michael D. Cole, Ph.D.

Professor of Molecular and Systems Biology

633 Rubin

Phone: 603-653-9975 


Our studies that focus on the genetic events involved in the induction of cancer provide an opportunity to define the molecular basis of the disease and to study the regulation and function of important eukaryotic genes that control cell proliferation.

Website | Email 

| Geisel Profile

Duane A. Compton, Ph.D.

Professor of Biochemistry and Cell Biology

Dean of Geisel School of Medicine

Office: 413 Remsen

Phone: 603-650-1190


We investigate the mechanisms that regulate accurate chromosome segregation in human cells and the causes of chromosomal instability in tumors.


Website | Email | PubMed Articles

 | Geisel Profile

Patrick J. Dolph, Ph.D.

Associate Professor of Biological Sciences

Office: 351 Life Sciences Center

Phone: 603-646-1092


Our laboratory utilizes Drosophila melanogaster as a model system to study retinal degeneration and molecular mechanisms of cell death.


Email | PubMed Articles

 | Faculty Profile

Jay C. Dunlap, Ph.D.

Nathan Smith Professor of Genetics, Chair and Professor of Molecular and Systems Biology, Professor of Biochemistry and Cell Biology

Office: 702 Remsen

Phone: 603-650-1108


Work in the Dunlap lab is directed towards understanding circadian biology, the means by which biological clocks operate, are reset by the environment, and control the metabolism of cells. More recently a second effort has nucleated around high throughput functional genomics of filamentous fungi including Neurospora and Aspergillus spp.

Website | Email | PubMed Articles | Geisel Profile

Scott A. Gerber, Ph.D.

Professor of Molecular and Systems Biology, and Biochemistry and Cell Biology

Office: 734 Rubin

Phone: 603-653-3679 


Research in the Gerber Lab is focused on developing and using modernproteomics methods to understand the mechanisms by which dysregulated mitotic kinases, such as Aurora kinase A, contribute to the onset and maintenance of cancers.

Website | Email | PubMed Articles

 | Geisel Profile

Erik E. Griffin, Ph.D.

Associate Professor of Biological Sciences

Office: 348 Life Sciences Center

Phone: 603-646-8269


We are interested in understanding how protein concentration gradients are generated in the cytoplasm and contribute to cell fate specification during development. We combine live imaging, biochemical and genetic approaches to study a series of cytoplasmic protein gradients that help pattern the early C. elegans embryo. 


Website | Email | PubMed Articles

 | Faculty Profile

Mary Lou Guerinot, Ph.D.

Ronald and Deborah Harris Professor in the Sciences, Professor of Biological Sciences, and Molecular and Systems Biology

Office: 325 Life Sciences Center

Phone: 603-646-2527


My principal expertise and research interests are in the area of metal transport and regulation of gene expression by metals. Plants are the major point of entry for essential metals into the food chain, so our work is laying the foundation for crops that offer sustainable solutions for malnutrition.


Website | Email | PubMed Articles | Faculty Profile

Bing He, Ph.D.

Assistant Professor of Biological Sciences

Office: 350 Life Sciences Center

Phone: 603-646-2649 


I am interested in how complex tissue and organ structures arise from simple tissue primordia. Using an interdisciplinary approach combining genetics, cell biology, biophysics and mathematical modeling, we seek to understand how developmental patterning information controls individual cell shape changes and how they are integrated into stereotyped tissue-scale deformations.


Website | Email 

| Faculty Profile

Henry N. Higgs, Ph.D.

Professor of Biochemistry and Cell Biology

Office: 403 Vail

Phone: 603-650-1520


Mammalian cells use actin filaments in a huge number of ways, and we are trying to figure out how cells control when and where specific actin-based structures are made. We use a combination of cellular (live-cell microscopy, fluorescence microscopy, EM, cell-free assays) and biochemical (actin polymerization kinetics, analytical ultracentrifugation, structural analysis) in our research.


Website | Email | PubMed Articles

 | Geisel Profile

Michael B. Hoppa, Ph.D.

Assistant Professor of Biological Sciences

Office: 345 Life Sciences

Phone: 603-646-8850


We explore the molecular mechanisms that control ion channel localization, expression and function in primary neurons using quantitative optical approaches in combination with genetic and biochemical tools. 


Website | Email | PubMed Articles | Faculty Profile

Arminja N. Kettenbach, Ph.D.

Associate Professor of Biochemistry and Cell Biology

Office: 763 Rubin 
Phone: 603-653-9067 


Research in the lab focuses on understanding the molecular mechanisms by which phosphatases contribute to phosphorylation-dependent signal transduction in mitosis. We use cell biological, biochemical, and proteomics approaches to decipher the connectivity and complexity of these signaling events in normal and cancer cells. 


Website | Email

 | Geisel Profile

Steven D. Leach, M.D.

Director of Norris Cotton Cancer Center

Preston T. and Virginia R. Kelsey Distinguished Chair in Cancer

Professor of Molecular and Systems Biology

Office: DH, Rubin Building, Room 801

Phone: 603-653-3611 


The Leach lab studies pancreatic developmental, epithelial and tumor biology, using mouse, zebrafish and human model sytems. 


Email | PubMed Articles

 | Geisel Profile

Jiwon Lee, Ph.D.

Ralph and Marjorie Crump Assistant Professor of Engineering

Thayer School of Engineering

Office:  751 Williamson Translational Research Building

Phone:  603-646-3485

The Lee Lab studies the dynamics of antibody repertoires in infectious disease, autoimmune disease, and cancer using high-throughput sequencing of B cell transcripts and high-resolution mass spectrometry. The repertoire of antibody molecules circulating in blood or coating mucosal surfaces is the basis for protective immunity, and we employ machine learning frameworks, big data analytics tools, proteomic analytical methods, and data modeling to gain clinically relevant insights regarding protective mechanisms at unprecedented details. Leveraging this knowledge, we aim to design next-generation therapeutics and vaccines precisely tailored to maximize effectiveness in the context of particular diseases and/or patients (i.e.personalized/precision medicine).

Website | Email | PubMed Articles 

Jennifer J. Loros, Ph.D.

Professor of Biochemistry, and Molecular and Systems Biology

Office: 704 Remsen

Phone: 603-650-1154


Our laboratories are interested in the genetic and molecular dissection of circadian systems in eukaryotic cells with a research emphasis on the fungus Neurospora and mammalian tissue culture. The circadian system comprises the core molecular feedback loop, how this loop feeds information to the cell and organism and how input to the loop via temperature changes and photoreceptors is regulated.


Website | Email | PubMed Articles

 | Geisel Profile

Dean R. Madden, Ph.D.

Professor of Biochemistry and Cell Biology

Dartmouth Vice Provost for Research

Office: 408A Vail

Phone: 603-650-1164


Structure and function of ion channels and proteins that regulate their intracellular trafficking.


Website | Email | PubMed Articles

 | Geisel Profile

Aaron McKenna, Ph.D.

Aaron McKenna, Ph.D.

Assistant Professor of Molecular and Systems Biology

Office:  Williamson Translational Building, Room 658

Phone:  603-650-1866

My lab is interested in how cells grow and divide to form complex structures, such as the transformation from the zygote to an adult human or from a transformed cell into a tumor mass. To study these processes, we develop technologies to trace pattern of cell divisions which recovers the lineage of each cell. This information can be combined with other measures of cell state such as single-cell transcriptomic data to develop a rich picture of how choices are made in development and how this process is dysregulated in diseases such as cancer.

Website | Email | PubMed Articles

Dale F. Mierke, Ph.D.

Professor of Chemistry, and Biochemistry and Cell Biology

Office: 202 Burke

Phone: 603-646-1154


Develop molecular inhibitors of specific protein-protein interactions which may find use as physiological tools or eventual therapeutic agents, using the structural features as determined from many experimental (mainly NMR) and computational techniques.


Email | PubMed Articles

 | Faculty Profile

James B. Moseley, Ph.D.

Associate Professor of Biochemistry and Cell Biology

Office: 412 Remsen

Phone: 603-650-1159

Many cell types delay cell cycle transitions until they reach a critical size threshold. We are studying the cellular mechanisms that measure size, and their role in coordinating cell growth and division.

Website | Email | PubMed Articles 

| Geisel Profile

Larry C. Myers, Ph.D.

Associate Professor of Medical Education, and Biochemistry and Cell Biology

Office: Vail 412

Phone: 603-650-1198

The goal of our lab is to determine how genetic and epigenetic information in eukaryotic cells is used to regulate the transcription of genes. We are particularly interested in how human fungal pathogens utilize epigenetic regulatory strategies to switch phenotypes and facilitate virulence.

Website | Email | PubMed Articles

 | Geisel Profile

Diwakar Pattabiraman Ph.D.

Assistant Professor of Molecular and Systems Biology, and Norris Cotton Cancer Center

Office: Rubin 602

Phone: 603-653-9957 


Our research focuses on understanding the genetic, epigenetic, signaling and cell biological aspects of tumor progression and metastasis in carcinomas. We study the role of transitions in epithelial and mesenchymal states within carcinomas as a model of understanding intratumoral heterogeneity to develop novel ways of overcoming metastatic progression and therapy resistance.


Website | Email | PubMed Articles

 | Geisel Profile

Benjamin D. Ross, Ph.D.

Assistant Professor of Microbiology and Immunology

Office:  504A Vail Building

Phone:

The bacteria resident in the human gastrointestinal tract (the gut microbiota) potently influence diverse aspects of human health, including immunity. However, the forces that govern the composition of the gut microbiota are poorly understood. Our work focuses on a mechanistic, ecological, and evolutionary understanding of how interbacterial interactions between members of the dominant Gram-negative bacteria in the gut, the Bacteroidales, modulate the composition of the microbiota. The Bacteroidales utilize a contact-dependent toxin-delivery system known as the type VI secretion system (T6SS) to kill neighboring cells. We study the impact of this pathway on the microbiota and how bacteria adapt to defend against T6SS-mediated antagonism, using a combination of bacterial genetics, biochemistry, metagenomics, and germ-free mouse models. We are also interested in understanding why Bacteroidales abundance is depleted in individuals with cystic fibrosis, with the goal of improving health through restoration of these bacteria.

Email | PubMed Articles

Yolanda Sanchez, Ph.D.

Associate Professor of Molecular and Systems Biology

Associate Director for Basic Sciences, Norris Cotton Cancer Center

Office:  Vail 501

Phone:  603-650-1669

Checkpoint signaling events triggered during the response to DNA damage or replication interference, how they regulate cell cycle progression, DNA repair and cell death.  The role of checkpoints in the etiology of cancer and as drug targets for therapeutic enhancers of genotoxic cancer drugs.

Website | Email  | Geisel Profile

G. Eric Schaller, Ph.D.

Professor of Biological Sciences

Office: 339 Life Sciences Center

Phone: 603-646-2525


Signal transduction by the plant hormones ethylene and cytokinin, and how these hormones act to control growth and development.


Website | Email | PubMed Articles

 | Faculty Profile

Daniel Schultz, Ph.D.

Assistant Professor of Microbiology and Immunology

Office: 206 Vail

Phone: 603-650-1644


The Schultz lab develops quantitative approaches to study the emergence, operation and optimization of the gene networks that control cell responses in bacteria, with a focus on antibiotic resistance mechanisms. We combine mathematical modeling, bioinformatics, experimental evolution and microfluidics to analyze how the cell controls the expression of resistance genes during drug responses. We strive to guide innovation in clinical therapies by uncovering the selective pressures that shape the evolution of antibiotic resistance in natural environments.

Website | Email | PubMed Articles

 | Geisel Profile

Christopher J. Shoemaker, Ph.D.

Assistant Professor of Biochemistry and Cell Biology

Office: 302B Vail

Phone: 603-650-1112

We are interested in the molecular mechanisms governing mammalian autophagy. We take a multidisciplinary approach involving CRISPR-based genetic screening, flow cytometry, quantitative microscopy and biochemical analysis.

Website | Email | PubMed Articles

 | Geisel Profile

Roger D. Sloboda, Ph.D.

Ira Allen Eastman Professor Biological Sciences

Office: 222 Life Sciences Center

Phone: 603-646-2377


We study microtubule dependent particle motility inside cells using intraflagellar transport (IFT) in the biflagellate green alga, Chlamydomonas and the primary cilia of MDCK cells in culture as the model systems.


Email | PubMed Articles

 | Faculty Profile

Elizabeth F. Smith, Ph.D.

Paul M. Danten Jr Professor

Professor of Biological Sciences

Dean of Faculty of Arts and Sciences

Office: 226 Life Sciences Center

Phone: 603-646-1129


The proper assembly and regulated function of eukaryotic cilia is critical for development and sustained human health. We use a variety of biochemical, molecular, and genetic techniques to elucidate the signal transduction pathways that regulate motor proteins responsible for ciliary beating.


Website | Email | PubMed Articles

 | Faculty Profile

Bruce Stanton, Ph.D.

Andrew C. Vail Memorial Professor

Professor of Microbiology and Immunology, and of Physiology

Office: 615 Remsen

Phone: 603-650-1775


Our laboratory studies the genetic disease Cystic Fibrosis. In particular we study host pathogen interactions between bacteria and human airway epithelial cells and the interactome of CFTR and how interacting proteins regulate CFTR trafficking. We also examine how environmental toxins, in particular arsenic, cause and contribute to respiratory and diseases and inflammation.


Website | Email | PubMed

 | Geisel Profile

Surachai Supattapone, M.D., Ph.D., D.Phil.

Professor of Biochemistry and Cell Biology, and Medicine

Office: 311 Vail

Phone: 603-650-1192

Our lab investigates the molecular mechanisms responsible for the propagation of protein misfolding in neurodegenerative diseases, with special focus on infectious mammalian prions.  We also use whole genome CRISPR libraries to study various areas of cell biology in mammalian cells.

Website | Email | PubMed Articles

 | Geisel Profile

Xiaofeng Wang, Ph.D.

Assistant Professor of Molecular and Systems Biology

Office: 632 Rubin

Phone:  603-653-9974


Our work focuses on cancer epigenetics. We are particularly interested in studying a family of chromatin remodeling complexes, which are frequently mutated in a variety of human cancers. Our work is aimed to understand how these mutations cause cancer, focusing on the regulation of chromatin structure dynamics (epigenomics) and chromatin remodeler protein complex assembly, as well as using genetic and chemical screens to identify potential therapeutic targets in human cancers. 


Email | PubMed Articles

 | Geisel Profile

William T. Wickner, M.D.

Professor of Biochemistry and Cell Biology

Office: 425 Remsen

Phone: 603-650-1701

We study how membrane vesicles fuse as they deliver new proteins, hormones, and neurotransmitters to their destinations.

Website | Email 

| Geisel Profile