Bioengineering Faculty

Margaret E. Ackerman, Ph.D.

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Margaret Ackerman

Professor of Engineering, and Microbiology and Immunology

Thayer School of Engineering

Office: 119B Cummings Hall


Phone: 603-646-9922

The Ackerman laboratory conducts interdisciplinary research at the interface of biomedical and engineering sciences: developing high throughput tools to evaluate the antibody response in disease states ranging from infection to cancer in order to aid in therapeutic antibody and vaccine design and development, and to understand the protective mechanism of antibodies using approaches grounded in fundamental engineering principles utilizing protein evolution, molecular biology, and mathematical modeling.

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Gevorg Grigoryan, Ph.D.

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Gevorg Grigoryan

Associate Professor of Computer Science, and Biological Sciences

Office: Sudikoff 113

Phone: 603-646-3173


We are interested in understanding the design principles underlying natural protein function on a quantitative, structure-based level. We employ a mix of computational and experimental approaches to both understand functions of natural proteins and engineer proteins with novel functionality. 


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Karl E. Griswold, Ph.D.

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Karl Griswold

Professor of Engineering, and Biological Sciences

Office: 128E Cummings Hall

Phone: 603-646-2127


The Griswold research group develops performance-enhanced biomolecules through the application of protein engineering technologies. Current projects are focused on biotherapeutic agents.


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Jiwon Lee, Ph.D.

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Jiwon Lee

Ralph and Marjorie Crump Assistant Professor of Engineering

Thayer School of Engineering

Office:  751 Williamson Translational Research Building

Phone:  603-646-3485

The Lee Lab studies the dynamics of antibody repertoires in infectious disease, autoimmune disease, and cancer using high-throughput sequencing of B cell transcripts and high-resolution mass spectrometry. The repertoire of antibody molecules circulating in blood or coating mucosal surfaces is the basis for protective immunity, and we employ machine learning frameworks, big data analytics tools, proteomic analytical methods, and data modeling to gain clinically relevant insights regarding protective mechanisms at unprecedented details. Leveraging this knowledge, we aim to design next-generation therapeutics and vaccines precisely tailored to maximize effectiveness in the context of particular diseases and/or patients (i.e.personalized/precision medicine).

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Lee R. Lynd, D.E.

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Lee Lynd

Paul E. / Joan H. Queneau Distinguished Professor in Environmental Engineering Design, and Professor of Biological Sciences

Office: 128D Cummings

Phone: 603-646-2231 


Professor Lynd is an expert on the production of energy from plant biomass and conducts leading research on microbial cellulose utilization. 


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Aaron McKenna, Ph.D.

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Aaron McKenna

Assistant Professor of Molecular and Systems Biology

Office:  Williamson Translational Building, Room 658

Phone:  603-650-1866

My lab is interested in how cells grow and divide to form complex structures, such as the transformation from the zygote to an adult human or from a transformed cell into a tumor mass. To study these processes, we develop technologies to trace pattern of cell divisions which recovers the lineage of each cell. This information can be combined with other measures of cell state such as single-cell transcriptomic data to develop a rich picture of how choices are made in development and how this process is dysregulated in diseases such as cancer.

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Kimberley Samkoe, Ph.D.

Kimberley Samkoe, Ph.D.

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Kimberley Samkoe

Associate Professor of Surgery, and Thayer School of Engineering

Office:   Borwell 536E

Phone:   650-7618

Brief research description: My research takes a biological-systems-engineering approach to medical imaging by studying how microscopic molecular information can be interpreted at a macro-scale. My current research interests involve quantitative assessment of in vivo protein expression and signaling using fluorescence molecular imaging. These methodologies have applications in cancer for improving tumor identification, surgical resection, and patient-specific therapeutic monitoring.

 

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Rahul Sarpeshkar, Ph.D.

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Rahul Sarpeshkar

Thomas E Kurtz Professor, Professor of Engineering, Microbiology and Immunology, Physics, Molecular and Systems Biology

Office: 507A Vail

Phone: 603-646-6821


Synthetic analog and digital biological circuits in electri-cigenic and other microbes; Applications of synthetic and systems biology to immunology, infectious disease, and cancer; Precision measurement, electronic circuit modeling, and feedback control of living cells at the fundamental limits set by physics.

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Daniel Schultz, Ph.D.

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Daniel Schultz

Assistant Professor of Microbiology and Immunology

Office: 206 Vail

Phone: 603-646-5390

The Schultz lab develops quantitative approaches to study the emergence, operation and optimization of the gene networks that control cell responses in bacteria, with a focus on antibiotic resistance mechanisms. We combine mathematical modeling, bioinformatics, experimental evolution and microfluidics to analyze how the cell controls the expression of resistance genes during drug responses. We strive to guide innovation in clinical therapies by uncovering the selective pressures that shape the evolution of antibiotic resistance in natural environments.

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Edward J. Usherwood, Ph.D.

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Edward Usherwood

Professor of Microbiology and Immunology

Office: 608E Borwell

Phone: 603-646-5224


Research in the Usherwood lab focuses on T cell-mediated immune surveillance to virus infections and cancer. We are interested in factors that regulate T cell memory and immune surveillance. A major goal is to exploit these findings to develop novel immunotherapies for cancer and persistent virus infections.

 

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