Developmental Biology (DEVB) Faculty

Yashi Ahmed, M.D., Ph.D.

 

Professor of Molecular and Systems Biology

Office: 613 Vail

Phone: 603-650-1027


We study the Adenomatous polyposis coli (APC) and Axin tumor suppressors and Beta-catenin oncogene, misregulation of which triggers development of colorectal carcinoma. We study the regulation of Beta-catenin by APC and Axin in Drosophila because the functions of these proteins are well conserved from flies to humans and powerful genetics approaches are available.

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Magdalena Bezanilla, Ph.D.

Ernest Everett Just 1907 Professor of Biological Sciences

Office: LSC 334

Phone: 603-646-2314


My research aims to understand how molecules within cells impart geometric information ultimately leading to cell shape determination. Research in my lab seeks to identify molecules within the cell that control cellular patterning. We are particularly interested in the role of regulators of the cytoskeleton and membrane trafficking and have pioneered the use of the moss Physcomitrella patens. Using the unusually rapid transgenic capabilities of moss, we are pursuing novel approaches to dissect the molecular mechanisms underlying plant cell shape.

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Giovanni Bosco, Ph.D.

Oscar M. Cohn Professor of Molecular and Systems Biology, Chair of MCB Program

Office: 609A Vail

Phone: 650-1210

We are interested in understanding how nuclear architecture, chromosome morphology and chromatin structure are modified in response to developmental cues and environmental factors. We are also interested in elucidating the molecular mechanisms through which these modifications function and effect specialized cellular processes.


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Zi Chen, Ph.D.

Assistant Professor of Engineering, and Biological Sciences

Office: MacLean 302

Phone: 603-646-6475


Dr. Chen's research interests range from biomechanics and mechanobiology to solid mechanics and material science, covering such diverse topics as mechanics of morphogenesis in biological systems, cell biomechanics, fast motion of plants, mechanics of DNA structures, mechanical instabilities of materials, energy harvesting, stretchable electronics, biomimetic materials/devices, nanofabrication, and modeling of 2D materials.

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Steven N. Fiering, Ph.D.

Professor of Microbiology and Immunology, and Molecular and Systems Biology

Office: 622 Rubin

Phone: 603-653-9966


My lab is working on novel approaches to detection and treatment of cancer. These approaches center on developing antitumor immune responses using nanoparticles and microorganisms. We are also generating novel mouse models of cancer and other diseases using genetically engineering mice.


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Erik E. Griffin, Ph.D.

Associate Professor of Biological Sciences

Office: 348 Life Sciences Center

Phone: 603-646-8269


We are interested in understanding how protein concentration gradients are generated in the cytoplasm and contribute to cell fate specification during development. We combine live imaging, biochemical and genetic approaches to study a series of cytoplasmic protein gradients that help pattern the early C. elegans embryo. 


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Bing He, Ph.D.

Assistant Professor of Biological Sciences

Office: 350 Life Sciences Center

Phone: 603-646-2649 


I am interested in how complex tissue and organ structures arise from simple tissue primordia. Using an interdisciplinary approach combining genetics, cell biology, biophysics and mathematical modeling, we seek to understand how developmental patterning information controls individual cell shape changes and how they are integrated into stereotyped tissue-scale deformations.


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Robert A. Hill Ph.D.

Assistant Professor of Biological Sciences

Office: 344 Life Sciences Center

Phone:

We study the multicellular interactions between neurons and glia in the brain with a primary focus on the development,plasticity, and regeneration of myelinating oligodendrocytes. Techniques include high-resolution optical imaging in combination with molecular labels, genetic manipulation, and sensors of cellular physiology.


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Steven D. Leach, M.D.

Director of Norris Cotton Cancer Center

Preston T. and Virginia R. Kelsey Distinguished Chair in Cancer

Professor of Molecular and Systems Biology

Office: DH, Rubin Building, Room 801

Phone: 603-653-3611 


The Leach lab studies pancreatic developmental, epithelial and tumor biology, using mouse, zebrafish and human model sytems. 


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Wei-Lih Lee, Ph.D.

Professor of Biological Sciences

Office: Class of 1978 Life Sciences Center, Room 224

Phone: 603-650-1154


I am interested in understanding how eukaryotic cells organize, position, and segregate their organelles during asymmetric cell divisions. We combine classical genetics and live-cell microscopy with biochemical and biophysical techniques to elucidate the molecular pathways that regulate the microtubule cytoskeleton and the motor proteins responsible for organellar interaction and positioning in our model system budding yeast.

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Bryan W. Luikart, Ph.D.

Associate Professor of Molecular and Systems Biology

Office: 604 Vail

Phone: 603-650-1633


We are interested in how gene mutations that cause autism alter neuronal development and function. To study this we engineer viruses to perform in vivo genetic manipulations and employ electrophysiology and multi-photon microscopy to study the impact of genetic manipulations on neuronal function. 


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Diwakar Pattabiraman Ph.D.

Assistant Professor of Molecular and Systems Biology, and Norris Cotton Cancer Center

Office: Rubin 602

Phone: 603-653-9957 


Our research focuses on understanding the genetic, epigenetic, signaling and cell biological aspects of tumor progression and metastasis in carcinomas. We study the role of transitions in epithelial and mesenchymal states within carcinomas as a model of understanding intratumoral heterogeneity to develop novel ways of overcoming metastatic progression and therapy resistance.


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Yolanda Sanchez, Ph.D.

Associate Professor of Molecular and Systems Biology

Associate Director for Basic Sciences, Norris Cotton Cancer Center

Office:  Vail 501

Phone:  603-650-1669

Checkpoint signaling events triggered during the response to DNA damage or replication interference, how they regulate cell cycle progression, DNA repair and cell death.  The role of checkpoints in the etiology of cancer and as drug targets for therapeutic enhancers of genotoxic cancer drugs.

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Hermes H. Yeh, Ph.D.

  • William W. Brown 1835 Memorial Professor
  • Professor of Molecular and Systems Biology, and Neurobiology
  • Director, Program in Experimental and Molecular Medicine
  • Office: 625 Remsen
  • Phone: 603-650-1698
  • Cellular and molecular mechanisms of neuroreceptor interactions and plasticity in the adult and developing CNS.

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