Associate Professor of Microbiology and Immunology
Office: 614W Borwell
Phone: 603-650-6899
Our research interests have the common theme of trying to understand how leukocytes modulate host immunity, both in response to bacterial infection and in response to cancer.
Distinguished Professor of Microbiology and Immunology
Office: 602W Borwell
Phone: 650-1168
My long-term research focus is to understand how bacterial toxins interact with the immune system to trigger pathogenesis or host protection. At Dartmouth, I will expand my research to investigate opportunistic bacterial pathogens that produce toxins and cause mucosal infections, such as those that occur in the lungs of Cystic Fibrosis patients. I will also be using synthetic immunology to develop novel therapeutics to combat opportunistic mucosal pathogens.
Professor of Microbiology and Immunology
Office: 654E Borwell
Phone: 603-650-7951
We are interested in understanding how the obligate intracellular parasite Toxoplasma gondii manipulates the mammalian host cell to ensure it's successful replication and triggering of host responses required for development and transmission. Our interests are the biological intersections of host-parasite interaction, pathogenesis, and immunity, while our goals are the development new drug therapies and vaccines against infectious diseases and cancer.
Professor of Microbiology and Immunology
Office: 210A Vail
Phone: 603-650-1740
Our major research interests are regulation of virulence gene in Staphylococcus aureus, a major human pathogen both in the community and in hospital settings.
Associate Professor of Microbiology and Immunology
Office: 213 Remsen
Phone: 603-650-1040
Our research group investigates the mechanisms by which the human fungal pathogen Aspergillus fumigates causes disease in immunocompromised patients. The main focus of our current studies is to understand the molecular mechanisms that Aspergillus and other human pathogenic fungi use to adapt to low oxygen microenvironments (hypoxia) that are found in vivo at sites of infection. In addition, we are exploring how hypoxia affects the innate immune response in patients at risk for invasive aspergillosis. We utilize molecular biology, genomics, biochemistry, microscopy, immunology, and animal model approaches to develop and explore our clinically relevant questions regarding these often lethal infections.
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Nathan Smith Professor of Genetics, Chair and Professor of Molecular and Systems Biology, Professor of Biochemistry and Cell Biology
Office: 702 Remsen
Phone: 603-650-1108
Work in the Dunlap lab is directed towards understanding circadian biology, the means by which biological clocks operate, are reset by the environment, and control the metabolism of cells. More recently a second effort has nucleated around high throughput functional genomics of filamentous fungi including Neurospora and Aspergillus spp.
Professor of Microbiology and Immunology
Office: 603W Borwell
Phone: 603-650-8607
Our research focuses on the T-cell immune responses to retroviruses.
Ronald and Deborah Harris Professor in the Sciences, Professor of Biological Sciences, and Molecular and Systems Biology
Office: 325 Life Sciences Center
Phone: 603-646-2527
My principal expertise and research interests are in the area of metal transport and regulation of gene expression by metals. Plants are the major point of entry for essential metals into the food chain, so our work is laying the foundation for crops that offer sustainable solutions for malnutrition.
Active Emeritus Professor of Microbiology and Immunology
Office: 646W Borwell
Phone: 603-650-7924
While fully engaged and serving on thesis committees, Dr. Guyre is no longer accepting thesis students. As cofounder of the successful human antibody company Medarex, and now VP for Research at Celdara Medical, Dr. Guyre is focused on helping students learn how to translate basic science into treatments that can help people. He also collaborates with clinical and basic science research faculty to investigate the mechanisms by which hormones and cytokines regulate the functional activity of white blood cells including monocytes, macrophages, dendritic cells, and neutrophils.
Associate Professor of Engineering and Microbiology and Immunology
Office: MacLean 305
Phone: 646-8656
Our research focuses on rapid, non-invasive detection and the tracking of infectious respiratory diseases using patient breath. Diseases we focus on range from acute pneumonias, such as those caused by influenza or bacterial agents like Klebsiella pneumoniae and Staphylococcus aureus, to chronic respiratory infections, such as those caused by Mycobacteria tuberculosis and Pseudomonas aeruginosa-dominant polymicrobial infections in patients with cystic fibrosis. We combine molecular biological, analytical chemistry, and 'big data' biostatistics tools when asking our metabolism-focused questions in the flask, animal model, or human patient. As such, our team consists of combinations of molecular biologists, microbiologist, chemists, engineers, medical doctors, and chemometricians.
Assistant Professor of Epidemiology, Biomedical Data Science, and Microbiology and Immunology
Office: 888 Rubin
Phone: 603-653-6087
Our work is on the development of the microbiome in infants and children, and the associations between environmental and dietary exposures, the microbiome, and risk for infectious diseases and other health outcomes.
Professor of Microbiology and Immunology
Office: 208 Vail
Phone: 603-650-1252
We study the mechanisms by which bacterial and fungal pathogens regulate virulence determinants within multicellular populations, within microbial communities and in the context of mammalian hosts.
Rodgers Professor of Chemistry, and Biochemistry and Cell Biology
Dean, Guarini School of Graduate and Advanced Sciences
Office: 304 Burke
Phone: 603-646-1552
Our laboratory uses biophysical techniques to study protein structure and function. Our goal is to understand at a fundamental level the conformational changes that occur in proteins as they complete the various cellular functions.
Professor and Chair of Microbiology and Immunology
Office: 630E Borwell
Phone: 603-650-8616
We study the molecular pathogenesis of herpes simplex virus. In particular, we are interested in ways that viruses evade both innate and adaptive immune responses.
Professor of Biochemistry, and Molecular and Systems Biology
Office: 704 Remsen
Phone: 603-650-1154
Our laboratories are interested in the genetic and molecular dissection of circadian systems in eukaryotic cells with a research emphasis on the fungus Neurospora and mammalian tissue culture. The circadian system comprises the core molecular feedback loop, how this loop feeds information to the cell and organism and how input to the loop via temperature changes and photoreceptors is regulated.
Professor of Biochemistry and Cell Biology
Dartmouth Vice Provost for Research
Office: 408A Vail
Phone: 603-650-1164
Structure and function of ion channels and proteins that regulate their intracellular trafficking.
Associate Professor of Medical Education, and Biochemistry and Cell Biology
Office: Vail 412
Phone: 603-650-1198
The goal of our lab is to determine how genetic and epigenetic information in eukaryotic cells is used to regulate the transcription of genes. We are particularly interested in how human fungal pathogens utilize epigenetic regulatory strategies to switch phenotypes and facilitate virulence.
Assistant Professor of Biological Sciences
Office: 326 Life Sciences Center
Phone: 603-646-1019
Bacteria often live in groups, called biofilms, where they cooperate and compete using a broad spectrum of interactive behaviors. These interactions are central to how bacteria evolve, and how they cause disease. We use molecular genetics, confocal microscopy, computational simulations, and evolutionary analysis to understand the mechanisms and biofilm-scale consequences of bacterial cell-cell interaction.
Thomas S. Kosasa Professor of Microbiology and Immunology
Office: 702 Rubin
Phone: 603-653-9908
We study mediators that control the development of adaptive immunity. Our current focus is on the role of retinoic acid in controlling immunity, elements of the immune microenvironment that control allograft tolerance and tumor immunity, and new members of the PD-L family that govern how monocytes regulate T cell responses.
Associate Professor of Microbiology and Immunology
Office: 650W Borwell
Phone: 603-650-6858
Research in the Obar lab investigates the mechanisms by which inflammatory leukocytes are recruited to the lungs during infections. Specifically, we are interested in viral infections, such as influenza A virus, and fungal infection, such as Aspergillus fumigatus.
Professor of Microbiology and Immunology
Office: 202 Remsen
Phone: 603-650-1248
My lab studies the molecular basis of biofilm formation on living and non-living surfaces, including the role of biofilms in disease. We also study host-pathogen interactions, and recently we have begun to explore the microbial communities associated with chronic lung infections, including cystic fibrosis.
Assistant Professor of Microbiology and Immunology
Office: 504B Vail Building
Phone:
The bacteria resident in the human gastrointestinal tract (the gut microbiota) potently influence diverse aspects of human health, including immunity. However, the forces that govern the composition of the gut microbiota are poorly understood. Our work focuses on a mechanistic, ecological, and evolutionary understanding of how interbacterial interactions between members of the dominant Gram-negative bacteria in the gut, the Bacteroidales, modulate the composition of the microbiota. The Bacteroidales utilize a contact-dependent toxin-delivery system known as the type VI secretion system (T6SS) to kill neighboring cells. We study the impact of this pathway on the microbiota and how bacteria adapt to defend against T6SS-mediated antagonism, using a combination of bacterial genetics, biochemistry, metagenomics, and germ-free mouse models. We are also interested in understanding why Bacteroidales abundance is depleted in individuals with cystic fibrosis, with the goal of improving health through restoration of these bacteria.
Thomas E Kurtz Professor of Engineering
Professor of Microbiology and Immunology, Molecular and Systems Biology, and Physiology
Office: 507A Vail
Phone: 603-646-6821
Synthetic analog and digital biological circuits in electri-cigenic and other microbes; Applications of synthetic and systems biology to immunology, infectious disease, and cancer; Precision measurement, electronic circuit modeling, and feedback control of living cells at the fundamental limits set by physics.
Assistant Professor of Microbiology and Immunology
Office: 206 Vail
Phone: 603-650-1644
The Schultz lab develops quantitative approaches to study the emergence, operation and optimization of the gene networks that control cell responses in bacteria, with a focus on antibiotic resistance mechanisms. We combine mathematical modeling, bioinformatics, experimental evolution and microfluidics to analyze how the cell controls the expression of resistance genes during drug responses. We strive to guide innovation in clinical therapies by uncovering the selective pressures that shape the evolution of antibiotic resistance in natural environments.
Professor of Microbiology and Immunology
Office: 640W Borwell
Phone: 603-650-8007
My laboratory is interested in innate immunity and how it regulates adaptive immunity in response to cancer and infectious disease. We focus our work on NK cells and CD8 T cells, and we are using innate immune receptors as a means to develop therapeutics for cancer.
Paul M. Danten Jr Professor
Professor of Biological Sciences
Dean of Faculty of Arts and Sciences
Office: 226 Life Sciences Center
Phone: 603-646-1129
The proper assembly and regulated function of eukaryotic cilia is critical for development and sustained human health. We use a variety of biochemical, molecular, and genetic techniques to elucidate the signal transduction pathways that regulate motor proteins responsible for ciliary beating.
Andrew C. Vail Memorial Professor
Professor of Microbiology and Immunology, and of Physiology
Office: 615 Remsen
Phone: 603-650-1775
Our laboratory studies the genetic disease Cystic Fibrosis. In particular we study host pathogen interactions between bacteria and human airway epithelial cells and the interactome of CFTR and how interacting proteins regulate CFTR trafficking. We also examine how environmental toxins, in particular arsenic, cause and contribute to respiratory and diseases and inflammation.
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Professor of Microbiology and Immunology
Office: 110 Vail
Phone: 603-650-1629
Molecular mechanisms of fungal pathogenesis and prevention of fungal disease for the most common fungal pathogen of man, Candida albicans.
Professor of Biochemistry and Cell Biology, and Medicine
Office: 311 Vail
Phone: 603-650-1192
Our lab investigates the molecular mechanisms responsible for the propagation of protein misfolding in neurodegenerative diseases such as prion and Alzheimer's disease.
Professor of Microbiology and Immunology
Office: 608E Borwell
Phone: 603-650-7730
Immunity to virus infections, T cell memory, the immune-virus interface in persistent virus infection.
Professor of Molecular and Systems Biology
Chair, Biomedical Data Science
Office: 705A Remsen
Phone: 603-650-1105
The complexities of biological systems can now be studied with genome-wide approaches that take a global view of the underlaying biology.
