Microbiology, Pathogenesis & Host-Microbe Interactions (M2P2) Faculty

Brent L. Berwin, Ph.D.

Associate Professor of Microbiology and Immunology

Office: 614W Borwell

Phone: 603-650-6899


Our research interests have the common theme of trying to understand how leukocytes modulate host immunity, both in response to bacterial infection and in response to cancer.

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James B. Bliska, Ph.D.

Distinguished Professor of Microbiology and Immunology

Office: 602W Borwell

Phone: 
650-1168

My long-term research focus is to understand how bacterial toxins interact with the immune system to trigger pathogenesis or host protection. At Dartmouth, I will expand my research to investigate opportunistic bacterial pathogens that produce toxins and cause mucosal infections, such as those that occur in the lungs of Cystic Fibrosis patients. I will also be using synthetic immunology to develop novel therapeutics to combat opportunistic mucosal pathogens.

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David J. Bzik, Ph.D.

Professor of Microbiology and Immunology

Office: 654E Borwell

Phone: 603-650-7951


We are interested in understanding how the obligate intracellular parasite Toxoplasma gondii manipulates the mammalian host cell to ensure it's successful replication and triggering of host responses required for development and transmission. Our interests are the biological intersections of host-parasite interaction, pathogenesis, and immunity, while our goals are the development new drug therapies and vaccines against infectious diseases and cancer.

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Ambrose Cheung, M.D.

Professor of Microbiology and Immunology

Office: 210A Vail

Phone: 603-650-1740 


Our major research interests are regulation of virulence gene in Staphylococcus aureus, a major human pathogen both in the community and in hospital settings.

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Robert A. Cramer, Ph.D.

Associate Professor of Microbiology and Immunology

Office: 213 Remsen

Phone: 603-650-1040


Our research group investigates the mechanisms by which the human fungal pathogen Aspergillus fumigates causes disease in immunocompromised patients. The main focus of our current studies is to understand the molecular mechanisms that Aspergillus and other human pathogenic fungi use to adapt to low oxygen microenvironments (hypoxia) that are found in vivo at sites of infection. In addition, we are exploring how hypoxia affects the innate immune response in patients at risk for invasive aspergillosis. We utilize molecular biology, genomics, biochemistry, microscopy, immunology, and animal model approaches to develop and explore our clinically relevant questions regarding these often lethal infections.


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Jay C. Dunlap, Ph.D.

Nathan Smith Professor of Genetics, Chair and Professor of Molecular and Systems Biology, Professor of Biochemistry and Cell Biology

Office: 702 Remsen

Phone: 603-650-1108


Work in the Dunlap lab is directed towards understanding circadian biology, the means by which biological clocks operate, are reset by the environment, and control the metabolism of cells. More recently a second effort has nucleated around high throughput functional genomics of filamentous fungi including Neurospora and Aspergillus spp.

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William R. Green, Ph.D.

Professor of Microbiology and Immunology

Office: 603W Borwell

Phone: 603-650-8607


Our research focuses on the T-cell immune responses to retroviruses.


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Mary Lou Guerinot, Ph.D.

Ronald and Deborah Harris Professor in the Sciences, Professor of Biological Sciences, and Molecular and Systems Biology

Office: 325 Life Sciences Center

Phone: 603-646-2527


My principal expertise and research interests are in the area of metal transport and regulation of gene expression by metals. Plants are the major point of entry for essential metals into the food chain, so our work is laying the foundation for crops that offer sustainable solutions for malnutrition.


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Paul M. Guyre, Ph.D.


Active Emeritus Professor of Microbiology and Immunology

Office: 646W Borwell

Phone: 603-650-7924

While fully engaged and serving on thesis committees, Dr. Guyre is no longer accepting thesis students. As cofounder of the successful human antibody company Medarex, and now VP for Research at Celdara Medical, Dr. Guyre is focused on helping students learn how to translate basic science into treatments that can help people. He also collaborates with clinical and basic science research faculty to investigate the mechanisms by which hormones and cytokines regulate the functional activity of white blood cells including monocytes, macrophages, dendritic cells, and neutrophils.

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Jane Hill, Ph.D.

Associate Professor of Engineering and Microbiology and Immunology

Office: MacLean 305 


Phone: 646-8656

Our research focuses on rapid, non-invasive detection and the tracking of infectious respiratory diseases using patient breath. Diseases we focus on range from acute pneumonias, such as those caused by influenza or bacterial agents like Klebsiella pneumoniae and Staphylococcus aureus, to chronic respiratory infections, such as those caused by Mycobacteria tuberculosis and Pseudomonas aeruginosa-dominant polymicrobial infections in patients with cystic fibrosis. We combine molecular biological, analytical chemistry, and 'big data' biostatistics tools when asking our metabolism-focused questions in the flask, animal model, or human patient. As such, our team consists of combinations of molecular biologists, microbiologist, chemists, engineers, medical doctors, and chemometricians.

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Anne G. Hoen, Ph.D., M.Phil.

Assistant Professor of Epidemiology, Biomedical Data Science, and Microbiology and Immunology

Office: 888 Rubin

Phone: 603-653-6087


Our work is on the development of the microbiome in infants and children, and the associations between environmental and dietary exposures, the microbiome, and risk for infectious diseases and other health outcomes.


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Deborah A. Hogan, Ph.D.

Professor of Microbiology and Immunology

Office: 208 Vail

Phone: 603-650-1252


We study the mechanisms by which bacterial and fungal pathogens regulate virulence determinants within multicellular populations, within microbial communities and in the context of mammalian hosts.


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F. Jon Kull, Ph.D.

Rodgers Professor of Chemistry, and Biochemistry and Cell Biology

Dean, Guarini School of Graduate and Advanced Sciences

Office: 304 Burke

Phone: 603-646-1552 


Our laboratory uses biophysical techniques to study protein structure and function. Our goal is to understand at a fundamental level the conformational changes that occur in proteins as they complete the various cellular functions. 


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David A. Leib, Ph.D.

Professor and Chair of Microbiology and Immunology

Office: 630E Borwell

Phone: 603-650-8616


We study the molecular pathogenesis of herpes simplex virus. In particular, we are interested in ways that viruses evade both innate and adaptive immune responses.


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Jennifer J. Loros, Ph.D.

Professor of Biochemistry, and Molecular and Systems Biology

Office: 704 Remsen

Phone: 603-650-1154


Our laboratories are interested in the genetic and molecular dissection of circadian systems in eukaryotic cells with a research emphasis on the fungus Neurospora and mammalian tissue culture. The circadian system comprises the core molecular feedback loop, how this loop feeds information to the cell and organism and how input to the loop via temperature changes and photoreceptors is regulated.


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Dean R. Madden, Ph.D.

Professor of Biochemistry and Cell Biology

Dartmouth Vice Provost for Research

Office: 408A Vail

Phone: 603-650-1164


Structure and function of ion channels and proteins that regulate their intracellular trafficking.


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Larry C. Myers, Ph.D.


Associate Professor of Medical Education, and Biochemistry and Cell Biology

Office: Vail 412

Phone: 603-650-1198

The goal of our lab is to determine how genetic and epigenetic information in eukaryotic cells is used to regulate the transcription of genes. We are particularly interested in how human fungal pathogens utilize epigenetic regulatory strategies to switch phenotypes and facilitate virulence.

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Carey D. Nadell, Ph.D.

Assistant Professor of Biological Sciences

Office: 326 Life Sciences Center

Phone: 603-646-1019


Bacteria often live in groups, called biofilms, where they cooperate and compete using a broad spectrum of interactive behaviors. These interactions are central to how bacteria evolve, and how they cause disease. We use molecular genetics, confocal microscopy, computational simulations, and evolutionary analysis to understand the mechanisms and biofilm-scale consequences of bacterial cell-cell interaction.


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Randolph J. Noelle, Ph.D.

Thomas S. Kosasa Professor of Microbiology and Immunology

Office: 702 Rubin

Phone: 603-653-9908


We study mediators that control the development of adaptive immunity. Our current focus is on the role of retinoic acid in controlling immunity, elements of the immune microenvironment that control allograft tolerance and tumor immunity, and new members of the PD-L family that govern how monocytes regulate T cell responses.


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Josh Obar, Ph.D.

Associate Professor of Microbiology and Immunology

Office: 650W Borwell

Phone: 603-650-6858


Research in the Obar lab investigates the mechanisms by which inflammatory leukocytes are recruited to the lungs during infections. Specifically, we are interested in viral infections, such as influenza A virus, and fungal infection, such as Aspergillus fumigatus. 


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George A. O'Toole, Ph.D.

Professor of Microbiology and Immunology

Office: 202 Remsen

Phone: 603-650-1248


My lab studies the molecular basis of biofilm formation on living and non-living surfaces, including the role of biofilms in disease. We also study host-pathogen interactions, and recently we have begun to explore the microbial communities associated with chronic lung infections, including cystic fibrosis.


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Rahul Sarpeshkar, Ph.D.

Thomas E Kurtz Professor of Engineering

Professor of Microbiology and Immunology, Molecular and Systems Biology, and Physiology

Office: 507A Vail

Phone: 603-646-6821


Synthetic analog and digital biological circuits in electri-cigenic and other microbes; Applications of synthetic and systems biology to immunology, infectious disease, and cancer; Precision measurement, electronic circuit modeling, and feedback control of living cells at the fundamental limits set by physics.

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Daniel Schultz, Ph.D.

Assistant Professor of Microbiology and Immunology

Office: 206 Vail

Phone: 603-650-1644


The Schultz lab develops quantitative approaches to study the emergence, operation and optimization of the gene networks that control cell responses in bacteria, with a focus on antibiotic resistance mechanisms. We combine mathematical modeling, bioinformatics, experimental evolution and microfluidics to analyze how the cell controls the expression of resistance genes during drug responses. We strive to guide innovation in clinical therapies by uncovering the selective pressures that shape the evolution of antibiotic resistance in natural environments.

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Charles L. Sentman, Ph.D.

Professor of Microbiology and Immunology

Office: 640W Borwell

Phone: 603-650-8007

My laboratory is interested in innate immunity and how it regulates adaptive immunity in response to cancer and infectious disease. We focus our work on NK cells and CD8 T cells, and we are using innate immune receptors as a means to develop therapeutics for cancer.


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Elizabeth F. Smith, Ph.D.

Paul M. Danten Jr Professor

Professor of Biological Sciences

Dean of Faculty of Arts and Sciences

Office: 226 Life Sciences Center

Phone: 603-646-1129


The proper assembly and regulated function of eukaryotic cilia is critical for development and sustained human health. We use a variety of biochemical, molecular, and genetic techniques to elucidate the signal transduction pathways that regulate motor proteins responsible for ciliary beating.


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Bruce Stanton, Ph.D.

Andrew C. Vail Memorial Professor

Professor of Microbiology and Immunology, and of Physiology

Office: 615 Remsen

Phone: 603-650-1775


Our laboratory studies the genetic disease Cystic Fibrosis. In particular we study host pathogen interactions between bacteria and human airway epithelial cells and the interactome of CFTR and how interacting proteins regulate CFTR trafficking. We also examine how environmental toxins, in particular arsenic, cause and contribute to respiratory and diseases and inflammation.


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Paula R. Sundstrom, Ph.D.

Professor of Microbiology and Immunology

Office: 110 Vail

Phone: 603-650-1629 


Molecular mechanisms of fungal pathogenesis and prevention of fungal disease for the most common fungal pathogen of man, Candida albicans.

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Surachai Supattapone, M.D., Ph.D., D.Phil.


Professor of Biochemistry and Cell Biology, and Medicine

Office: 311 Vail

Phone: 603-650-1192

Our lab investigates the molecular mechanisms responsible for the propagation of protein misfolding in neurodegenerative diseases such as prion and Alzheimer's disease.

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Edward J. Usherwood, Ph.D.

Professor of Microbiology and Immunology

Office: 608E Borwell

Phone: 603-650-7730


Immunity to virus infections, T cell memory, the immune-virus interface in persistent virus infection.


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Michael Whitfield, Ph.D.

Molecular and Systems Biology

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