Assistant Professor of Chemistry, and Biochemistry and Cell Biology
Office: 203 Burke
The Robustelli laboratory integrates computational methods with biophysical experiments to obtain atomic-level descriptions of the functional motions of biomolecules, with a particular interest in intrinsically disordered proteins. We aim to use insights from atomistic molecular simulations to understand, predict and design binding interactions of dynamic of disordered proteins and to elucidate general principles governing molecular recognition in dynamic systems. A current focus of our laboratory is understanding the thermodynamic driving forces of small molecule ligands binding to disordered protein sequences, with the goal of providing new avenues to therapeutic interventions in diseases associated with disordered protein dysfunction through the rational design of small molecule and biologic inhibitors.
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