Associate Professor of Computer Science, and Biological Sciences
Office: Sudikoff 113
Phone: 603-646-3173
We are interested in understanding the design principles underlying natural protein function on a quantitative, structure-based level. We employ a mix of computational and experimental approaches to both understand functions of natural proteins and engineer proteins with novel functionality.
Associate Professor of Molecular and Systems Biology
Office: 601 Vail
Phone: 603-646-5249
Our research focus is the cerebral cortex, an area of the brain that serves as the biological substrate for the higher cognitive functions that define us as individuals. We wish to identify the mechanisms by which individual cortical neurons process and transmit information within the cortical circuit. To accomplish this we employ electrical and optical recording techniques that measure neuronal activity in neocortical neurons under a variety of experimental conditions.
Assistant Professor of Biological Sciences
Office: 350 Life Sciences Center
Phone: 603-646-2649
I am interested in how complex tissue and organ structures arise from simple tissue primordia. Using an interdisciplinary approach combining genetics, cell biology, biophysics and mathematical modeling, we seek to understand how developmental patterning information controls individual cell shape changes and how they are integrated into stereotyped tissue-scale deformations.
Associate Professor of Biological Sciences, Co-Director of Integrative Neuroscience at Dartmouth Graduate Program
Office: 345 Life Sciences
Phone: 603-646-8850
We explore the molecular mechanisms that control ion channel localization, expression and function in primary neurons using quantitative optical approaches in combination with genetic and biochemical tools.
Rodgers Professor of Chemistry, and Biochemistry and Cell Biology
Dean, Guarini School of Graduate and Advanced Sciences
Office: 304 Burke
Phone: 603-646-1552
Our laboratory uses biophysical techniques to study protein structure and function. Our goal is to understand at a fundamental level the conformational changes that occur in proteins as they complete the various cellular functions.
Office: Class of 1978 Life Sciences Center, Room 224
Phone: 603-646-8706
I am interested in understanding how eukaryotic cells organize, position, and segregate their organelles during asymmetric cell divisions. We combine classical genetics and live-cell microscopy with biochemical and biophysical techniques to elucidate the molecular pathways that regulate the microtubule cytoskeleton and the motor proteins responsible for organellar interaction and positioning in our model system budding yeast.
Professor of Biochemistry and Cell Biology
Dartmouth Vice Provost for Research
Office: 408A Vail
Phone: 603-646-5197
Structure and function of ion channels and proteins that regulate their intracellular trafficking.
Professor of Chemistry, and Biochemistry and Cell Biology
Office: 202 Burke
Phone: 603-646-1154
Develop molecular inhibitors of specific protein-protein interactions which may find use as physiological tools or eventual therapeutic agents, using the structural features as determined from many experimental (mainly NMR) and computational techniques.
Associate Professor of Chemistry, and Biochemistry and Cell Biology
Office: 114 Burke
Phone: 603-546-2501
Our studies examine the interplay between protein dynamics and redox reactivity in signaling transformations and address fundamental problems in reaction mechanisms, coordination chemistry and biology.
Associate Professor of Chemistry, and Biochemistry and Cell Biology
Office: 221 Burke
Phone: 603-646-9066
Autophagy is a catabolic cellular process capable of degrading large cellular material including organelles and aggregates. We are interested in elucidating the molecular mechanisms of autophagy through a combination of X-ray crystallography, small angle X-ray scattering and biochemistry.
Assistant Professor of Chemistry, and Biochemistry and Cell Biology
Office: 203 Burke
Phone: 603-646-2270
The Robustelli laboratory integrates computational methods with biophysical experiments to obtain atomic-level descriptions of the functional motions of biomolecules, with a particular interest in intrinsically disordered proteins. We aim to use insights from atomistic molecular simulations to understand, predict and design binding interactions of dynamic of disordered proteins and to elucidate general principles governing molecular recognition in dynamic systems. A current focus of our laboratory is understanding the thermodynamic driving forces of small molecule ligands binding to disordered protein sequences, with the goal of providing new avenues to therapeutic interventions in diseases associated with disordered protein dysfunction through the rational design of small molecule and biologic inhibitors.
Assistant Professor of Microbiology and Immunology
Office: 206 Vail
Phone: 603-646-5390
The Schultz lab develops quantitative approaches to study the emergence, operation and optimization of the gene networks that control cell responses in bacteria, with a focus on antibiotic resistance mechanisms. We combine mathematical modeling, bioinformatics, experimental evolution and microfluidics to analyze how the cell controls the expression of resistance genes during drug responses. We strive to guide innovation in clinical therapies by uncovering the selective pressures that shape the evolution of antibiotic resistance in natural environments.
Professor of Biochemistry and Cell Biology, and Medicine
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Office: 311 Vail
Phone: 603-646-5212
Our lab investigates the molecular mechanisms responsible for the propagation of protein misfolding in neurodegenerative diseases, with special focus on infectious mammalian prions. We also use whole genome CRISPR libraries to study various areas of cell biology in mammalian cells.