Kali Smolen

Kettenbach lab

Kali is a Michigan native who received her Bachelor's in Cell and Molecular Biology from Grand Valley State University in Allendale, MI. As an MD-PhD student at Dartmouth, she conducts research in the lab of Dr. Arminja Kettenbach in the Biochemistry and Cell Biology (BCB) Department. She studies the regulation of phosphatases in biochemical pathways. More specifically, her work focuses on the regulation of B56, a family of regulatory subunits of protein phosphatase 2A (PP2A) and the role of the PP2A-B56 holoenzyme in the DNA damage response via its signaling through Oxidative Resistance 1 (OXR1). When not in lab, Kali enjoys road and mountain biking, backcountry skiing, riding her horse named Gucci, growing vegetables, cooking without recipes, and trail running in the mountains.  

Contact

Kali.A.Smolen.MED@dartmouth.edu
6168448284
HB Hinman Box 7937

Selected Publications

  • Papke CM, Smolen KA, Swingle MR, Cressey L, Heng RA, Toporsian M, Deng L, Hagen J, Shen Y, Chung WK, Kettenbach AN, Honkanen RE (2021). A disorder-related variant (E420K) of a PP2A-regulatory subunit (PPP2R5D) causes constitutively active AKT-mTOR signaling and uncoordinated cell growth. J Biol Chem:100313. PMCID: PMC7952134

    Curtis BN, Smolen KA, Barlow SJ, Caselli E, Prati F, Taracila MA, Bonomo RA, Wallar BJ, Powers RA (2020). Structural Insights into Inhibition of the Acinetobacter-Derived Cephalosporinase ADC-7 by Ceftazidime and Its Boronic Acid Transition State Analog. Antimicrob Agents Chemother 64(12). PMCID: PMC7674067

    Caselli E, Fini F, Introvigne ML, Stucchi M, Taracila MA, Fish ER, Smolen KA, Rather PN, Powers RA, Wallar BJ, Bonomo RA, Prati F (2020). 1,2,3-Triazolylmethaneboronate: A Structure Activity Relationship Study of a Class of beta-Lactamase Inhibitors against Acinetobacter baumannii Cephalosporinase. ACS Infect Dis 6(7):1965-1975. PMCID: PMC7458062
     
    Caselli E, Romagnoli C, Powers RA, Taracila MA, Bouza AA, Swanson HC, Smolen KA, Fini F, Wallar BJ, Bonomo RA, Prati F (2018). Inhibition of Acinetobacter-Derived Cephalosporinase: Exploring the Carboxylate Recognition Site Using Novel beta Lactamase Inhibitors. ACS Infect Dis 4(3):337-348. PMCID: PMC5987196

    Bouza AA, Swanson HC, Smolen KA, VanDine AL, Taracila MA, Romagnoli C, Caselli E, Prati F, Bonomo RA, Powers RA, Wallar BJ (2018). Structure-Based Analysis of Boronic Acids as Inhibitors of Acinetobacter-Derived Cephalosporinase-7, a Unique Class C
    beta-Lactamase.ACS Infect Dis 4(3):325-336. PMCID: PMC5981863