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The broad goal of Dr. Salas's research is to investigate how cell heterogeneity impacts human populations health and disease, emphasizing how genetic, environmental, and lifestyle factors model the human epigenome and, therefore, cell plasticity. Dr. Salas' laboratory studies how some key epigenetic mechanisms (DNA methylation, DNA hydroxymethylation, chromatin accessibility, and miRNA alterations) affect gene expression and cancer outcomes, including how the immune cells are altered in this disease.