Luke Deary

Wang lab

Luke is a graduate of Washington and Lee University. He received a BS degree in Biology with a Classics minor. In our Molecular and Cellular Biology graduate program, Luke is a member of the Wang lab in the Norris Cotton Cancer Center. He studies the role of SWI/SNF chromatin remodeling complexes in maintenance of intestinal stem cell identity and their loss of function in colorectal cancers. His hobbies include skiing, hiking and guitar. 

Contact

Luke.T.Deary.GR@dartmouth.edu
9785053597
HB Hinman Box 7936

Selected Publications

  • Carlone DL, Riba-Wolman RD, Deary LT, Tovaglieri A, Jiang L, Ambruzs DM, Mead BE, Shah MS, Lengner CJ, Jaenisch R, Breault DT. Telomerase expression marks transitional growth-associated skeletal progenitor/stem cells. Stem Cells. 2021 Mar;39(3):296-305. doi: 10.1002/stem.3318. Epub 2021 Jan 13. PMID: 33438789.
     
    Richmond CA, Shah MS, Deary LT, Trotier DC, Thomas H, Ambruzs DM, Jiang L, Whiles BB, Rickner HD, Montgomery RK, Tovaglieri A, Carlone DL, Breault DT. Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status. Cell Rep. 2015 Dec 22;13(11):2403-2411. doi: 10.1016/j.celrep.2015.11.035. Epub 2015 Dec 10. PMID: 26686631; PMCID: PMC4691543.

    Wolf BK, Zhao Y, McCray A, Hawk WH, Deary LT, Sugiarto NW, LaCroix IS, Gerber SA, Cheng C, Wang X. Cooperation of chromatin remodeling SWI/SNF complex and pioneer factor AP-1 shapes 3D enhancer landscapes. Nat Struct Mol Biol. 2023 Jan;30(1):10-21. doi: 10.1038/s41594-022-00880-x. Epub 2022 Dec 15. PMID: 36522426.

    Hinds JW, Feris EJ, Wilkins OM, Deary LT, Wang X, Cole MD. S146L in MYC is a context-dependent activating substitution in cancer development. PLoS One. 2022 Aug 26;17(8):e0272771. doi: 10.1371/journal.pone.0272771. PMID: 36018850; PMCID: PMC9417018.

    Richmond CA, Rickner H, Shah MS, Ediger T, Deary L, Zhou F, Tovaglieri A, Carlone DL, Breault DT. JAK/STAT-1 Signaling Is Required for Reserve Intestinal Stem Cell Activation during Intestinal Regeneration Following Acute Inflammation. Stem Cell Reports. 2018 Jan 9;10(1):17-26. doi: 10.1016/j.stemcr.2017.11.015. Epub 2017 Dec 21. PMID: 29276155; PMCID: PMC5768934.