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Nicholas received his B.A. in Biochemistry & Molecular Biology from Hendrix College. He was appointed as a trainee for the MCB training grant, served as an elected student representative for the MCB Graduate Committee and was selected as a Fellow of the Albert J. Ryan Foundation. Nicholas is in the Madden lab in our Biochemistry and Cell biology department where he utilizes an array of biochemical, structural, and computational techniques to develop peptide- and small molecule-based inhibitors of CAL, a scaffolding protein implicated in the disease cystic fibrosis. Nicholas enjoys being outside with his wife and dog and spending time skiing.
Seisel Q, Rädisch M, Gill NP, Madden DR, Boisguerin P. (2017). Optimization of the process of inverted peptides (PIPEPLUS) to screen PDZ domain ligands. Bioorg. Med. Chem. Lett. 27, 3111–3116.
Holt GT, Jou JD, Gill NP, Lowegard AU, Martin JW, Madden DR, Donald BR. (2019). Computational analysis of energy landscapes reveals dynamic features that contribute to binding of inhibitors to CFTR-associated ligand. J. Phys. Chem "B". 123, 10441-10455.