Pamela Rosato

Our research focuses on understanding the function and regulation of virus-specific resident memory T cells (TRM). Using mouse and human tissue explant models, we seek to develop a foundational understanding of TRM biology in distinct tissues to be able to contextualize the role of TRM in pathologic and protective settings. Our current focuses are on the functions of anti-viral TRM in the brain, repurposing virus-specific TRM as a brain tumor immunotherapy, and investigating the role of TRM within tumors during oncolytic viral therapy.