All MCB Faculty

Margaret E. Ackerman, Ph.D.

Associate Professor of Engineering, and Microbiology and Immunology

Thayer School of Engineering

Office: 119B Cummings Hall


Phone: 603-646-9922

The Ackerman laboratory conducts interdisciplinary research at the interface of biomedical and engineering sciences: developing high throughput tools to evaluate the antibody response in disease states ranging from infection to cancer in order to aid in therapeutic antibody and vaccine design and development, and to understand the protective mechanism of antibodies using approaches grounded in fundamental engineering principles utilizing protein evolution, molecular biology, and mathematical modeling.

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Yashi Ahmed, M.D., Ph.D.

 

Professor of Molecular and Systems Biology

Office: 613 Vail

Phone: 603-650-1027


We study the Adenomatous polyposis coli (APC) and Axin tumor suppressors and Beta-catenin oncogene, misregulation of which triggers development of colorectal carcinoma. We study the regulation of Beta-catenin by APC and Axin in Drosophila because the functions of these proteins are well conserved from flies to humans and powerful genetics approaches are available.

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Charles K. Barlowe, Ph.D.

James C. Chilcott 1920 Professor and Chair of Biochemistry and Cell Biology

Office: 414 Remsen

Phone: 603-650-6516


My research group investigates intracellular trafficking and we seek to understand the molecular mechanisms that control protein transport through the early secretory pathway. We use a multidisciplinary approach that includes biochemistry, molecular genetics, proteomics and microscopy in model systems.

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Brent L. Berwin, Ph.D.

Associate Professor of Microbiology and Immunology

Office: 614W Borwell

Phone: 603-650-6899


Our research interests have the common theme of trying to understand how leukocytes modulate host immunity, both in response to bacterial infection and in response to cancer.

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Magdalena Bezanilla, Ph.D.

Ernest Everett Just 1907 Professor of Biological Sciences

Office: LSC 334

Phone: 603-646-2314


My research aims to understand how molecules within cells impart geometric information ultimately leading to cell shape determination. Research in my lab seeks to identify molecules within the cell that control cellular patterning. We are particularly interested in the role of regulators of the cytoskeleton and membrane trafficking and have pioneered the use of the moss Physcomitrella patens. Using the unusually rapid transgenic capabilities of moss, we are pursuing novel approaches to dissect the molecular mechanisms underlying plant cell shape.

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Sharon E. Bickel, Ph.D.

Associate Professor of Biological Sciences

Office: 238 Life Sciences Center

Phone: 603-646-0245


Chromosome segregation errors in human oocytes are the leading cause of miscarriages and birth defects and their frequency increases dramatically as women age. Work in my laboratory is focused on defining the pathway of events necessary for chromosomes to ""do the right thing"" during meiosis and understanding the molecular events that cause reduced fidelity of meiotic chromosome segregation as oocytes age.

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James B. Bliska, Ph.D.

Distinguished Professor of Microbiology and Immunology

Office: 602W Borwell

Phone: 
650-1168

My long-term research focus is to understand how bacterial toxins interact with the immune system to trigger pathogenesis or host protection. At Dartmouth, I will expand my research to investigate opportunistic bacterial pathogens that produce toxins and cause mucosal infections, such as those that occur in the lungs of Cystic Fibrosis patients. I will also be using synthetic immunology to develop novel therapeutics to combat opportunistic mucosal pathogens.

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Giovanni Bosco, Ph.D.

Oscar M. Cohn Professor of Molecular and Systems Biology, Chair of MCB Program

Office: 609A Vail

Phone: 650-1210

We are interested in understanding how nuclear architecture, chromosome morphology and chromatin structure are modified in response to developmental cues and environmental factors. We are also interested in elucidating the molecular mechanisms through which these modifications function and effect specialized cellular processes.


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David J. Bzik, Ph.D.

Professor of Microbiology and Immunology

Office: 654E Borwell

Phone: 603-650-7951


We are interested in understanding how the obligate intracellular parasite Toxoplasma gondii manipulates the mammalian host cell to ensure it's successful replication and triggering of host responses required for development and transmission. Our interests are the biological intersections of host-parasite interaction, pathogenesis, and immunity, while our goals are the development new drug therapies and vaccines against infectious diseases and cancer.

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T.Y. Chang, Ph.D.

Professor of Biochemistry and Cell Biology

Office: 304 Vail

Phone: 603-650-1622


The enzyme acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) is a membrane bound protein located at the endoplasmic reticulum. It plays important roles in health and in diseases. Our laboratory identified the ACAT1 gene. We are conducting structure-function analysis of ACAT1 in vitro, and taking mouse genetic approaches to determine the pathophysiological role of ACAT1 in Alzheimer's disease, in atherosclerosis, and in diet-induced obesity.

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Zi Chen, Ph.D.

Assistant Professor of Engineering, and Biological Sciences

Office: MacLean 302

Phone: 603-646-6475


Dr. Chen's research interests range from biomechanics and mechanobiology to solid mechanics and material science, covering such diverse topics as mechanics of morphogenesis in biological systems, cell biomechanics, fast motion of plants, mechanics of DNA structures, mechanical instabilities of materials, energy harvesting, stretchable electronics, biomimetic materials/devices, nanofabrication, and modeling of 2D materials.

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Ambrose Cheung, M.D.

Professor of Microbiology and Immunology

Office: 210A Vail

Phone: 603-650-1740 


Our major research interests are regulation of virulence gene in Staphylococcus aureus, a major human pathogen both in the community and in hospital settings.

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Michael D. Cole, Ph.D.

Professor of Molecular and Systems Biology

633 Rubin

Phone: 603-653-9975 


Our studies that focus on the genetic events involved in the induction of cancer provide an opportunity to define the molecular basis of the disease and to study the regulation and function of important eukaryotic genes that control cell proliferation.

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Duane A. Compton, Ph.D.

Professor of Biochemistry and Cell Biology

Dean of Geisel School of Medicine

Office: 413 Remsen

Phone: 603-650-1190


We investigate the mechanisms that regulate accurate chromosome segregation in human cells and the causes of chromosomal instability in tumors.


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Robert A. Cramer, Ph.D.

Associate Professor of Microbiology and Immunology

Office: 213 Remsen

Phone: 603-650-1040


Our research group investigates the mechanisms by which the human fungal pathogen Aspergillus fumigates causes disease in immunocompromised patients. The main focus of our current studies is to understand the molecular mechanisms that Aspergillus and other human pathogenic fungi use to adapt to low oxygen microenvironments (hypoxia) that are found in vivo at sites of infection. In addition, we are exploring how hypoxia affects the innate immune response in patients at risk for invasive aspergillosis. We utilize molecular biology, genomics, biochemistry, microscopy, immunology, and animal model approaches to develop and explore our clinically relevant questions regarding these often lethal infections.


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Patrick J. Dolph, Ph.D.

Associate Professor of Biological Sciences

Office: 351 Life Sciences Center

Phone: 603-646-1092


Our laboratory utilizes Drosophila melanogaster as a model system to study retinal degeneration and molecular mechanisms of cell death.


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Jay C. Dunlap, Ph.D.

Nathan Smith Professor of Genetics, Chair and Professor of Molecular and Systems Biology, Professor of Biochemistry and Cell Biology

Office: 702 Remsen

Phone: 603-650-1108


Work in the Dunlap lab is directed towards understanding circadian biology, the means by which biological clocks operate, are reset by the environment, and control the metabolism of cells. More recently a second effort has nucleated around high throughput functional genomics of filamentous fungi including Neurospora and Aspergillus spp.

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Steven N. Fiering, Ph.D.

Professor of Microbiology and Immunology, and Molecular and Systems Biology

Office: 622 Rubin

Phone: 603-653-9966


My lab is working on novel approaches to detection and treatment of cancer. These approaches center on developing antitumor immune responses using nanoparticles and microorganisms. We are also generating novel mouse models of cancer and other diseases using genetically engineering mice.


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Scott A. Gerber, Ph.D.

Professor of Molecular and Systems Biology, and Biochemistry and Cell Biology

Office: 734 Rubin

Phone: 603-653-3679 


Research in the Gerber Lab is focused on developing and using modernproteomics methods to understand the mechanisms by which dysregulated mitotic kinases, such as Aurora kinase A, contribute to the onset and maintenance of cancers.

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Tillman U. Gerngross, Ph.D.

Professor of Engineering, and Biological Sciences

Office: 128E Cummings Hall

Phone: 603-646-3161 


Protein engineering; glycoprotein engineering; high cell density fermentation technology; metabolic engineering; protein expression.

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William R. Green, Ph.D.

Professor of Microbiology and Immunology

Office: 603W Borwell

Phone: 603-650-8607


Our research focuses on the T-cell immune responses to retroviruses.


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Erik E. Griffin, Ph.D.

Associate Professor of Biological Sciences

Office: 348 Life Sciences Center

Phone: 603-646-8269


We are interested in understanding how protein concentration gradients are generated in the cytoplasm and contribute to cell fate specification during development. We combine live imaging, biochemical and genetic approaches to study a series of cytoplasmic protein gradients that help pattern the early C. elegans embryo. 


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Gevorg Grigoryan, Ph.D.

Associate Professor of Computer Science, and Biological Sciences

Office: Sudikoff 113

Phone: 603-646-3173


We are interested in understanding the design principles underlying natural protein function on a quantitative, structure-based level. We employ a mix of computational and experimental approaches to both understand functions of natural proteins and engineer proteins with novel functionality. 


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Karl E. Griswold, Ph.D.

Associate Professor of Engineering, and Biological Sciences

Office: 128E Cummings Hall

Phone: 603-646-2127


The Griswold research group develops performance-enhanced biomolecules through the application of protein engineering technologies. Current projects are focused on biotherapeutic agents.


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Mary Lou Guerinot, Ph.D.

Ronald and Deborah Harris Professor in the Sciences, Professor of Biological Sciences, and Molecular and Systems Biology

Office: 325 Life Sciences Center

Phone: 603-646-2527


My principal expertise and research interests are in the area of metal transport and regulation of gene expression by metals. Plants are the major point of entry for essential metals into the food chain, so our work is laying the foundation for crops that offer sustainable solutions for malnutrition.


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Allan Gulledge, Ph.D.

Associate Professor of Molecular and Systems Biology

Office: 601 Vail

Phone: 603-650-1222

Our research focus is the cerebral cortex, an area of the brain that serves as the biological substrate for the higher cognitive functions that define us as individuals. We wish to identify the mechanisms by which individual cortical neurons process and transmit information within the cortical circuit. To accomplish this we employ electrical and optical recording techniques that measure neuronal activity in neocortical neurons under a variety of experimental conditions.


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Paul M. Guyre, Ph.D.


Active Emeritus Professor of Microbiology and Immunology

Office: 646W Borwell

Phone: 603-650-7924

While fully engaged and serving on thesis committees, Dr. Guyre is no longer accepting thesis students. As cofounder of the successful human antibody company Medarex, and now VP for Research at Celdara Medical, Dr. Guyre is focused on helping students learn how to translate basic science into treatments that can help people. He also collaborates with clinical and basic science research faculty to investigate the mechanisms by which hormones and cytokines regulate the functional activity of white blood cells including monocytes, macrophages, dendritic cells, and neutrophils.

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Bing He, Ph.D.

Assistant Professor of Biological Sciences

Office: 350 Life Sciences Center

Phone: 603-646-2649 


I am interested in how complex tissue and organ structures arise from simple tissue primordia. Using an interdisciplinary approach combining genetics, cell biology, biophysics and mathematical modeling, we seek to understand how developmental patterning information controls individual cell shape changes and how they are integrated into stereotyped tissue-scale deformations.


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Henry N. Higgs, Ph.D.

Professor of Biochemistry and Cell Biology

Office: 403 Vail

Phone: 603-650-1520


Mammalian cells use actin filaments in a huge number of ways, and we are trying to figure out how cells control when and where specific actin-based structures are made. We use a combination of cellular (live-cell microscopy, fluorescence microscopy, EM, cell-free assays) and biochemical (actin polymerization kinetics, analytical ultracentrifugation, structural analysis) in our research.


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Jane Hill, Ph.D.

Associate Professor of Engineering and Microbiology and Immunology

Office: MacLean 305 


Phone: 646-8656

Our research focuses on rapid, non-invasive detection and the tracking of infectious respiratory diseases using patient breath. Diseases we focus on range from acute pneumonias, such as those caused by influenza or bacterial agents like Klebsiella pneumoniae and Staphylococcus aureus, to chronic respiratory infections, such as those caused by Mycobacteria tuberculosis and Pseudomonas aeruginosa-dominant polymicrobial infections in patients with cystic fibrosis. We combine molecular biological, analytical chemistry, and 'big data' biostatistics tools when asking our metabolism-focused questions in the flask, animal model, or human patient. As such, our team consists of combinations of molecular biologists, microbiologist, chemists, engineers, medical doctors, and chemometricians.

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Robert A. Hill Ph.D.

Assistant Professor of Biological Sciences

Office: 344 Life Sciences Center

Phone:

We study the multicellular interactions between neurons and glia in the brain with a primary focus on the development,plasticity, and regeneration of myelinating oligodendrocytes. Techniques include high-resolution optical imaging in combination with molecular labels, genetic manipulation, and sensors of cellular physiology.


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Anne G. Hoen, Ph.D., M.Phil.

Assistant Professor of Epidemiology, Biomedical Data Science, and Microbiology and Immunology

Office: 888 Rubin

Phone: 603-653-6087


Our work is on the development of the microbiome in infants and children, and the associations between environmental and dietary exposures, the microbiome, and risk for infectious diseases and other health outcomes.


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Deborah A. Hogan, Ph.D.

Professor of Microbiology and Immunology

Office: 208 Vail

Phone: 603-650-1252


We study the mechanisms by which bacterial and fungal pathogens regulate virulence determinants within multicellular populations, within microbial communities and in the context of mammalian hosts.


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Michael B. Hoppa, Ph.D.

Assistant Professor of Biological Sciences

Office: 345 Life Sciences

Phone: 603-646-8850


We explore the molecular mechanisms that control ion channel localization, expression and function in primary neurons using quantitative optical approaches in combination with genetic and biochemical tools. 


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Yina H. Huang, Ph.D.

Associate Professor of Microbiology and Immunology, and Pathology and Lab Medicine

Office: 604E Borwell

Phone: 603-650-7545 


We investigate how T cells traffic and respond to infections and tumors. In particular, we study the signals that regulate differentiation and migration of effector and memory T cell and are exploring methods to manipulate their activity to ensure protective and durable immune protection. 


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Thomas P. Jack, Ph.D.

Professor and Chair of Biological Sciences

Office: 331 Life Sciences Center

Phone: 603-646-3367


Molecular Genetics of flower development in Arabidopsis thaliana.


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Arminja N. Kettenbach, Ph.D.

Associate Professor of Biochemistry and Cell Biology

Office: 763 Rubin 
Phone: 603-653-9067 


Research in the lab focuses on understanding the molecular mechanisms by which phosphatases contribute to phosphorylation-dependent signal transduction in mitosis. We use cell biological, biochemical, and proteomics approaches to decipher the connectivity and complexity of these signaling events in normal and cancer cells. 


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F. Jon Kull, Ph.D.

Rodgers Professor of Chemistry, and Biochemistry and Cell Biology

Dean, Guarini School of Graduate and Advanced Sciences

Office: 304 Burke

Phone: 603-646-1552 


Our laboratory uses biophysical techniques to study protein structure and function. Our goal is to understand at a fundamental level the conformational changes that occur in proteins as they complete the various cellular functions. 


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Steven D. Leach, M.D.

Director of Norris Cotton Cancer Center

Preston T. and Virginia R. Kelsey Distinguished Chair in Cancer

Professor of Molecular and Systems Biology

Office: DH, Rubin Building, Room 801

Phone: 603-653-3611 


The Leach lab studies pancreatic developmental, epithelial and tumor biology, using mouse, zebrafish and human model sytems. 


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Wei-Lih Lee, Ph.D.

Professor of Biological Sciences

Office: Class of 1978 Life Sciences Center, Room 224

Phone: 603-650-1154


I am interested in understanding how eukaryotic cells organize, position, and segregate their organelles during asymmetric cell divisions. We combine classical genetics and live-cell microscopy with biochemical and biophysical techniques to elucidate the molecular pathways that regulate the microtubule cytoskeleton and the motor proteins responsible for organellar interaction and positioning in our model system budding yeast.

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David A. Leib, Ph.D.

Professor and Chair of Microbiology and Immunology

Office: 630E Borwell

Phone: 603-650-8616


We study the molecular pathogenesis of herpes simplex virus. In particular, we are interested in ways that viruses evade both innate and adaptive immune responses.


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Jennifer J. Loros, Ph.D.

Professor of Biochemistry, and Molecular and Systems Biology

Office: 704 Remsen

Phone: 603-650-1154


Our laboratories are interested in the genetic and molecular dissection of circadian systems in eukaryotic cells with a research emphasis on the fungus Neurospora and mammalian tissue culture. The circadian system comprises the core molecular feedback loop, how this loop feeds information to the cell and organism and how input to the loop via temperature changes and photoreceptors is regulated.


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Bryan W. Luikart, Ph.D.

Associate Professor of Molecular and Systems Biology

Office: 604 Vail

Phone: 603-650-1633


We are interested in how gene mutations that cause autism alter neuronal development and function. To study this we engineer viruses to perform in vivo genetic manipulations and employ electrophysiology and multi-photon microscopy to study the impact of genetic manipulations on neuronal function. 


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Lee R. Lynd, D.E.

Paul E. / Joan H. Queneau Distinguished Professor in Environmental Engineering Design, and Professor of Biological Sciences

Office: 128D Cummings

Phone: 603-646-2231 


Professor Lynd is an expert on the production of energy from plant biomass and conducts leading research on microbial cellulose utilization. 


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Dean R. Madden, Ph.D.

Professor of Biochemistry and Cell Biology

Dartmouth Vice Provost for Research

Office: 408A Vail

Phone: 603-650-1164


Structure and function of ion channels and proteins that regulate their intracellular trafficking.


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Robert A. Maue, Ph.D.

Professor of Medical Education, and Biochemistry and Cell Biology

Office: 210 Remsen

Phone: 603-650-1726

We are interested in understanding the mechanisms important for the development and differentiation of neurons in the brain. 


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C. Robertson McClung, Ph.D.

Patricia F. / William B. Hale 1944 Professor in the Arts and Sciences, Professor of Biological Sciences

Office: 323 Life Sciences Center

Phone: 603-646-3940


The ability of an organism to measure time is the product of a cellular biological clock. Many phenomena controlled by the biological clock cycle on a daily basis and are called circadian rhythms. My goal is to understand the genetic and biochemical mechanisms by which a plant measures time and uses that temporal information to regulate gene expression and cellular physiology.


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Dale F. Mierke, Ph.D.

Professor of Chemistry, and Biochemistry and Cell Biology

Office: 202 Burke

Phone: 603-646-1154


Develop molecular inhibitors of specific protein-protein interactions which may find use as physiological tools or eventual therapeutic agents, using the structural features as determined from many experimental (mainly NMR) and computational techniques.


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James B. Moseley, Ph.D.


Associate Professor of Biochemistry and Cell Biology

Office: 412 Remsen

Phone: 603-650-1159

Many cell types delay cell cycle transitions until they reach a critical size threshold. We are studying the cellular mechanisms that measure size, and their role in coordinating cell growth and division.

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David W. Mullins, Ph.D.

Associate Professor of Medical Education, and Microbiology and Immunology

Office:  232 Remsen

Phone:  603-650-1208

Our lab studies the molecular mechanisms that govern T cell infiltration of metastatic cancers. We translate our basic research findings into novel therapies that induce or augment immune cell infiltration of refractory tumors, thereby enhancing the clinical efficacy of immunotherapy.


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Larry C. Myers, Ph.D.


Associate Professor of Medical Education, and Biochemistry and Cell Biology

Office: Vail 412

Phone: 603-650-1198

The goal of our lab is to determine how genetic and epigenetic information in eukaryotic cells is used to regulate the transcription of genes. We are particularly interested in how human fungal pathogens utilize epigenetic regulatory strategies to switch phenotypes and facilitate virulence.

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Carey D. Nadell, Ph.D.

Assistant Professor of Biological Sciences

Office: 326 Life Sciences Center

Phone: 603-646-1019


Bacteria often live in groups, called biofilms, where they cooperate and compete using a broad spectrum of interactive behaviors. These interactions are central to how bacteria evolve, and how they cause disease. We use molecular genetics, confocal microscopy, computational simulations, and evolutionary analysis to understand the mechanisms and biofilm-scale consequences of bacterial cell-cell interaction.


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Randolph J. Noelle, Ph.D.

Thomas S. Kosasa Professor of Microbiology and Immunology

Office: 702 Rubin

Phone: 603-653-9908


We study mediators that control the development of adaptive immunity. Our current focus is on the role of retinoic acid in controlling immunity, elements of the immune microenvironment that control allograft tolerance and tumor immunity, and new members of the PD-L family that govern how monocytes regulate T cell responses.


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Josh Obar, Ph.D.

Associate Professor of Microbiology and Immunology

Office: 650W Borwell

Phone: 603-650-6858


Research in the Obar lab investigates the mechanisms by which inflammatory leukocytes are recruited to the lungs during infections. Specifically, we are interested in viral infections, such as influenza A virus, and fungal infection, such as Aspergillus fumigatus. 


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George A. O'Toole, Ph.D.

Professor of Microbiology and Immunology

Office: 202 Remsen

Phone: 603-650-1248


My lab studies the molecular basis of biofilm formation on living and non-living surfaces, including the role of biofilms in disease. We also study host-pathogen interactions, and recently we have begun to explore the microbial communities associated with chronic lung infections, including cystic fibrosis.


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Diwakar Pattabiraman Ph.D.

Assistant Professor of Molecular and Systems Biology, and Norris Cotton Cancer Center

Office: Rubin 602

Phone: 603-653-9957 


Our research focuses on understanding the genetic, epigenetic, signaling and cell biological aspects of tumor progression and metastasis in carcinomas. We study the role of transitions in epithelial and mesenchymal states within carcinomas as a model of understanding intratumoral heterogeneity to develop novel ways of overcoming metastatic progression and therapy resistance.


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Patricia A. Pioli, Ph.D.

Assistant Professor of Microbiology and Immunology

Office: 644E Borwell Building

Phone: 603-650-2584 


Research in our laboratory is focused on identifying the molecular mechanisms that regulate macrophage activation in the context of both autoimmunity and cancer. Taking advantage of macrophage plasticity, we then use this information to determine how macrophage activation can be altered for maximal therapeutic benefit.


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Ekaterina V. Pletneva, Ph.D.


Associate Professor of Chemistry, and Biochemistry and Cell Biology

Office: 114 Burke

Phone: 603-546-2501

Our studies examine the interplay between protein dynamics and redox reactivity in signaling transformations and address fundamental problems in reaction mechanisms, coordination chemistry and biology.

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Michael J. Ragusa, Ph.D.


Assistant Professor of Chemistry, and Biochemistry and Cell Biology

Office: 221 Burke

Phone: 603-646-9066

Autophagy is a catabolic cellular process capable of degrading large cellular material including organelles and aggregates. We are interested in elucidating the molecular mechanisms of autophagy through a combination of X-ray crystallography, small angle X-ray scattering and biochemistry.

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William F.C. Rigby, M.D.

Professor of Medicine, and Microbiology and Immunology

Office: 608W Borwell

Phone: 603-646-7912

Dr. Rigby is examining the changes that accompany clinical responses in patients with rheumatoid arthritis treated with biologics.


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Yolanda Sanchez, Ph.D.

Associate Professor of Molecular and Systems Biology

Associate Director for Basic Sciences, Norris Cotton Cancer Center

Office:  Vail 501

Phone:  603-650-1669

Checkpoint signaling events triggered during the response to DNA damage or replication interference, how they regulate cell cycle progression, DNA repair and cell death.  The role of checkpoints in the etiology of cancer and as drug targets for therapeutic enhancers of genotoxic cancer drugs.

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Rahul Sarpeshkar, Ph.D.

Thomas E Kurtz Professor of Engineering

Professor of Microbiology and Immunology, Molecular and Systems Biology, and Physiology

Office: 507A Vail

Phone: 603-646-6821


Synthetic analog and digital biological circuits in electri-cigenic and other microbes; Applications of synthetic and systems biology to immunology, infectious disease, and cancer; Precision measurement, electronic circuit modeling, and feedback control of living cells at the fundamental limits set by physics.

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G. Eric Schaller, Ph.D.

Professor of Biological Sciences

Office: 339 Life Sciences Center

Phone: 603-646-2525


Signal transduction by the plant hormones ethylene and cytokinin, and how these hormones act to control growth and development.


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Daniel Schultz, Ph.D.

Assistant Professor of Microbiology and Immunology

Office: 206 Vail

Phone: 603-650-1644


The Schultz lab develops quantitative approaches to study the emergence, operation and optimization of the gene networks that control cell responses in bacteria, with a focus on antibiotic resistance mechanisms. We combine mathematical modeling, bioinformatics, experimental evolution and microfluidics to analyze how the cell controls the expression of resistance genes during drug responses. We strive to guide innovation in clinical therapies by uncovering the selective pressures that shape the evolution of antibiotic resistance in natural environments.

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Charles L. Sentman, Ph.D.

Professor of Microbiology and Immunology

Office: 640W Borwell

Phone: 603-650-8007

My laboratory is interested in innate immunity and how it regulates adaptive immunity in response to cancer and infectious disease. We focus our work on NK cells and CD8 T cells, and we are using innate immune receptors as a means to develop therapeutics for cancer.


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Christopher J. Shoemaker, Ph.D.


Assistant Professor of Biochemistry and Cell Biology

Office: 302B Vail

Phone: 603-650-1112

We are interested in the molecular mechanisms governing mammalian autophagy. We take a multidisciplinary approach involving CRISPR-based genetic screening, flow cytometry, quantitative microscopy and biochemical analysis.

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Roger D. Sloboda, Ph.D.

Ira Allen Eastman Professor Biological Sciences

Office: 222 Life Sciences Center

Phone: 603-646-2377


We study microtubule dependent particle motility inside cells using intraflagellar transport (IFT) in the biflagellate green alga, Chlamydomonas and the primary cilia of MDCK cells in culture as the model systems.


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Elizabeth F. Smith, Ph.D.

Paul M. Danten Jr Professor

Professor of Biological Sciences

Dean of Faculty of Arts and Sciences

Office: 226 Life Sciences Center

Phone: 603-646-1129


The proper assembly and regulated function of eukaryotic cilia is critical for development and sustained human health. We use a variety of biochemical, molecular, and genetic techniques to elucidate the signal transduction pathways that regulate motor proteins responsible for ciliary beating.


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Bruce Stanton, Ph.D.

Andrew C. Vail Memorial Professor

Professor of Microbiology and Immunology, and of Physiology

Office: 615 Remsen

Phone: 603-650-1775


Our laboratory studies the genetic disease Cystic Fibrosis. In particular we study host pathogen interactions between bacteria and human airway epithelial cells and the interactome of CFTR and how interacting proteins regulate CFTR trafficking. We also examine how environmental toxins, in particular arsenic, cause and contribute to respiratory and diseases and inflammation.


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Paula R. Sundstrom, Ph.D.

Professor of Microbiology and Immunology

Office: 110 Vail

Phone: 603-650-1629 


Molecular mechanisms of fungal pathogenesis and prevention of fungal disease for the most common fungal pathogen of man, Candida albicans.

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Surachai Supattapone, M.D., Ph.D., D.Phil.


Professor of Biochemistry and Cell Biology, and Medicine

Office: 311 Vail

Phone: 603-650-1192

Our lab investigates the molecular mechanisms responsible for the propagation of protein misfolding in neurodegenerative diseases such as prion and Alzheimer's disease.

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Mary Jo Turk, Ph.D.


Professor of Microbiology and Immunology

Office: 732 Rubin

Phone: 603-653-3549

Our research focuses on understanding how the immune system responds to cancer, with an emphasis on T cell memory. We are also interested in learning how autoimmunity influences anti-tumor immunity.

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Edward J. Usherwood, Ph.D.

Professor of Microbiology and Immunology

Office: 608E Borwell

Phone: 603-650-7730


Immunity to virus infections, T cell memory, the immune-virus interface in persistent virus infection.


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Xiaofeng Wang, Ph.D.

Assistant Professor of Molecular and Systems Biology

Office: 632 Rubin

Phone:  603-653-9974


Our work focuses on cancer epigenetics. We are particularly interested in studying a family of chromatin remodeling complexes, which are frequently mutated in a variety of human cancers. Our work is aimed to understand how these mutations cause cancer, focusing on the regulation of chromatin structure dynamics (epigenomics) and chromatin remodeler protein complex assembly, as well as using genetic and chemical screens to identify potential therapeutic targets in human cancers. 


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Michael L. Whitfield, Ph.D.

Professor of Molecular and Systems Biology

Acting Director, Biomedical Date Science

Office: 705A Remsen

Phone: 603-650-1105 


The complexities of biological systems can now be studied with genome-wide approaches that take a global view of the underlaying biology. 


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William T. Wickner, M.D.


Professor of Biochemistry and Cell Biology

Office: 425 Remsen

Phone: 603-650-1701

We study how membrane vesicles fuse as they deliver new proteins, hormones, and neurotransmitters to their destinations.

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Hermes H. Yeh, Ph.D.

William W. Brown 1835 Memorial Professor

Professor of Molecular and Systems Biology, and Neurobiology

Director, Program in Experimental and Molecular Medicine

Office: 625 Remsen

Phone: 603-650-1698

Cellular and molecular mechanisms of neuroreceptor interactions and plasticity in the adult and developing CNS.

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Olga Zhaxybayeva, Ph.D.

Associate Professor of Biological Sciences

Office: 333 Life Sciences Center

Phone: 603-646-8616


My lab's research focus is to better understand evolution of microbes through computational analyses of genomic and metagenomic data.


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