All MCB Faculty

Margaret E. Ackerman, Ph.D.

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Margaret Ackerman

Professor of Engineering, and Microbiology and Immunology

Thayer School of Engineering

Office: 119B Cummings Hall


Phone: 603-646-9922

The Ackerman laboratory conducts interdisciplinary research at the interface of biomedical and engineering sciences: developing high throughput tools to evaluate the antibody response in disease states ranging from infection to cancer in order to aid in therapeutic antibody and vaccine design and development, and to understand the protective mechanism of antibodies using approaches grounded in fundamental engineering principles utilizing protein evolution, molecular biology, and mathematical modeling.

Website | Email | PubMed Articles  | Geisel Profile

Yashi Ahmed, M.D., Ph.D.

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Yashi Ahmed

Professor of Molecular and Systems Biology

Office: 613 Vail

Phone: 603-646-5240

The evolutionarily conserved Wnt signal transduction pathway directs cell proliferation and differentiation during animal development and tissue homeostasis. Despite the fact that deregulation of Wnt signaling underlies numerous developmental disorders and cancers, including nearly all colorectal cancers, many of these mechanisms remain poorly understood. The long-term goal of research in the Ahmed Lab is to elucidate the mechanisms that activate Wnt signaling during animal development using a Drosophila model and to use this knowledge to identify control points in the pathway susceptible to therapeutic targeting in Wnt-driven diseases.

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AMANDA A. AMODEO, Ph.D.

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Amanda Amodeo

Assistant Professor of Biological Sciences

Office:  223 Life Sciences Center

Phone:  603-646-9926

My lab seeks to uncover how cell size, zygotic genome activation, chromatin regulation, and the cell cycle come together to regulate early development in the Drosophila embryo. We use a combination of quantitative imaging, cell biology, genetics, genomics, biochemistry, and mathematical modeling to answer questions about how cells sense fundamental biological properties such as their size and developmental stage.

Website / Email / PubMed Articles

Alix Ashare, M.D., Ph.D.

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Alix Ashare

Associate Professor of Medicine, and Microbiology and Immunology

Office:  Borwell 508E

Phone:  603-650-5533

My research focuses on the role of lung macrophages in the development and persistence of inflammation in the lung. A major focus of my laboratory is the investigation of potential mechanisms underlying regional heterogeneity of lung inflammation in patients with inflammatory lung diseases, with an emphasis on the investigation of differences in alveolar macrophage function in patients with cystic fibrosis and asthma. Our work involves primary human immune cells isolated from patients with cystic fibrosis and asthma, as well as healthy volunteers and chronic smokers. Currently, my laboratory is particularly interested in how the lung environment impacts resident and recruited macrophage phenotype and function and how these changes in the immune cell may contribute to the non-resolving inflammation seen in patients with CF. In addition to our work in inflammatory lung diseases such as CF, we are investigating the relationship between impaired lipid homeostasis in lung macrophages and viral immunity in individuals who use electronic cigarettes.

Email / Website / PubMed 

Prachee Avasthi, Ph.D.

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Prachee Avasthi

Associate Professor of Biochemistry and Cell Biology

Office:  Vail 409A

Phone:  603-646-5177

We are a fundamental cell biology lab using genetics, bioche­mistry, chemical biology, microscopy, and quantitative image analysis to probe how signaling and trafficking coordinate to build higher order cytoskeletal structures. We use the simplest and most powerful model system appropriate for our studies, a yeast-like alga Chlamydomonas reinhardtii,to study a conserved microtubule-based sensory organelle, the cilium. Defects in cilia, which are found on nearly all human cells, can cause blindness, kidney disease, diabetes, cancer, and other disorders.  We also study organization and regulation of the actin cytoskeleton, which we previously found has a major role in ciliary assembly. Lab projects span a wide array of topics including cytoskeletal dynamics, intracellular trafficking, and signal-dependent organelle regulation.

Website / Email / PubMed Articles /

Charles K. Barlowe, Ph.D.

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Charles Barlowe

James C. Chilcott 1920 Professor and Chair of Biochemistry and Cell Biology

Office: 414 Remsen

Phone: 603-646-5180

My research group investigates intracellular trafficking and we seek to understand the molecular mechanisms that control protein transport and quality control in the early secretory pathway. We use a multidisciplinary approach that includes biochemistry, molecular genetics, proteomics and microscopy in model systems.

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Magdalena Bezanilla, Ph.D.

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Magdalena Bezanilla

Ernest Everett Just 1907 Professor of Biological Sciences

Chair of the MCB Program

Office: LSC 334

Phone: 603-646-2314


My research aims to understand how molecules within cells impart geometric information ultimately leading to cell shape determination. Research in my lab seeks to identify molecules within the cell that control cellular patterning. We are particularly interested in the role of regulators of the cytoskeleton and membrane trafficking and have pioneered the use of the moss Physcomitrella patens. Using the unusually rapid transgenic capabilities of moss, we are pursuing novel approaches to dissect the molecular mechanisms underlying plant cell shape.

Website | Email | PubMed Articles | Faculty Profile

Sharon E. Bickel, Ph.D.

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Sharon Bickel
Professor of Biological Sciences

Office: 237 Life Sciences Center

Phone: 603-646-0245


Chromosome segregation errors in human oocytes are the leading cause of miscarriages and birth defects and their frequency increases dramatically as women age. Work in my laboratory is focused on defining the pathway of events necessary for chromosomes to "do the right thing"" during meiosis and understanding the molecular events that cause reduced fidelity of meiotic chromosome segregation as oocytes age.

Website | Email | PubMed Articles

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James B. Bliska, Ph.D.

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James Bliska
Distinguished Professor of Microbiology and Immunology

Office: 524A Remsen

Phone: 
646-5346

My long-term research focus is to understand how bacterial toxins interact with the immune system to trigger pathogenesis or host protection. At Dartmouth, I will expand my research to investigate opportunistic bacterial pathogens that produce toxins and cause mucosal infections, such as those that occur in the lungs of Cystic Fibrosis patients. I will also be using synthetic immunology to develop novel therapeutics to combat opportunistic mucosal pathogens.

Email | PubMed Articles

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Giovanni Bosco, Ph.D.

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Giovanni Bosco

Oscar M. Cohn Professor of Molecular and Systems Biology

Office: 609A Vail

Phone: 646-5241

We are interested in understanding how nuclear architecture, chromosome morphology and chromatin structure are modified in response to developmental cues and environmental factors. We are also interested in elucidating the molecular mechanisms through which these modifications function and effect specialized cellular processes.


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David J. Bzik, Ph.D.

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David Bzik

Professor of Microbiology and Immunology

Office: 654E Borwell

Phone: 603-646-5348

We are interested in understanding how the obligate intracellular parasite Toxoplasma gondii manipulates the mammalian host cell to ensure it's successful replication and triggering of host responses required for development and transmission. Our interests are the biological intersections of host-parasite interaction, pathogenesis, and immunity, while our goals are the development new drug therapies and vaccines against infectious diseases and cancer.

Email | PubMed Articles

 | Geisel Profile

T.Y. Chang, Ph.D.

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Ta Yuan Chang

Professor of Biochemistry and Cell Biology

Office: 304 Vail

Phone: 603-646-5183

Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is a membrane protein located in the endoplasmic reticulum. It catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty acyl-coenzyme A. Cholesteryl ester is the storage form of cholesterol. The first gene encoding the enzyme ACAT1 was identified in our laboratory. We have also purified this protein to homogeneity and characterized it biochemically. In many neurodegenerative diseases, the cholesterol-rich microdomains in the membranes of various cell types are disrupted. We have shown that in mouse models for Alzheimer's disease and for Niemann Pick type C disease, inactivating ACAT1 can divert the cholesterol storage pool, such that the "mobilized cholesterol" can repair the disrupted cholesterol-rich microdomains. Future investigations are directed to develop novel ACAT inhibitors to ameliorate Alzheimer's disease, Niemann-Pick type C disease, and atherosclerosis. We will also use biochemical and biophysical approaches to identify the active sites and regulatory sites in ACAT1 and to investigate the mechanistic consequence of inhibiting ACAT in macrophages, neurons, microglia, and astrocytes. 

Website | Email | PubMed Articles

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Ambrose Cheung, M.D.

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Ambrose Cheung

Professor of Microbiology and Immunology

Office:  210A Vail

Phone:  603-646-5350

Our major research interests are regulation of virulence gene in Staphylococcus aureus, a major human pathogen both in the community and in hospital settings.

 

BROCK CHRISTENSEN, PH.D.

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Brock Christensen

Professor of Epidemiology, and Molecular Systems Biology

Office:  660 Williamson Building

Phone:  603-650-1827

Dr. Christensen's research is focused on combining advances in molecular biology, genomics and bioinformatics with the powerful techniques of modern epidemiology and statistics to characterize epigenetic states in human health and disease. His interests include understanding relationships between epigenetic states and exposures in the context of disease susceptibility, occurrence, and progression. By investigating complex interactions between the environment and somatic epigenetic alterations in target tissues, as well as epigenetic susceptibility traits in surrogate tissues, he hopes to develop their potential translational utility for diagnostic, prognostic, and/or treatment purposes.

 

Website  Email   PubMed Articles

Michael D. Cole, Ph.D.

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Michael Cole

Professor of Molecular and Systems Biology

633 Rubin

Phone: 603-653-9975 


Our studies that focus on the genetic events involved in the induction of cancer provide an opportunity to define the molecular basis of the disease and to study the regulation and function of important eukaryotic genes that control cell proliferation.

Website | Email 

| Geisel Profile

Duane A. Compton, Ph.D.

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Duane Compton

Professor of Biochemistry and Cell Biology

Dean of Geisel School of Medicine

Office: 413 Remsen

Phone: 603-646-5190

We investigate the mechanisms that regulate accurate chromosome segregation in human cells and the causes of chromosomal instability in tumors.


Website | Email | PubMed Articles

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Robert A. Cramer, Ph.D.

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Robert A. Cramer

Professor of Microbiology and Immunology

Office: 213 Remsen

Phone: 603-646-5352

Our research group investigates the molecular mechanisms through which the human fungal pathogen Aspergillus fumigatus causes disease in diverse patient populations. We utilize molecular genetics, genomics, biochemistry, microscopy, immunology, and animal model approaches to develop, explore, and test our clinically relevant questions and hypotheses regarding these too often lethal infections.
 Our long-term goal is to translate results from these studies into novel therapeutic advances.

Website | Email | PubMed

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Patrick J. Dolph, Ph.D.

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Patrick Dolph

Associate Professor of Biological Sciences

Office: 351 Life Sciences Center

Phone: 603-646-1092


Our laboratory utilizes Drosophila melanogaster as a model system to study retinal degeneration and molecular mechanisms of cell death.


Email | PubMed Articles

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Jay C. Dunlap, Ph.D.

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Jay C. Dunlap

Nathan Smith Professor of Genetics, Professor of Molecular and Systems Biology, Professor of Biochemistry and Cell Biology

Office: 702 Remsen

Phone: 603-646-5247

Work in the Dunlap lab is directed towards understanding circadian biology, the means by which biological clocks operate, are reset by the environment, and control the metabolism of cells. More recently a second effort has nucleated around high throughput functional genomics of filamentous fungi including Neurospora and Aspergillus spp.

Website | Email | PubMed Articles | Geisel Profile

Steven N. Fiering, Ph.D.

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Steven N. Fiering

Professor of Microbiology and Immunology, and Molecular and Systems Biology

Office: 622 Rubin

Phone: 603-646-5365


My lab is working on novel approaches to detection and treatment of cancer. These approaches center on developing antitumor immune responses using nanoparticles and microorganisms. We are also generating novel mouse models of cancer and other diseases using genetically engineering mice.


Email | PubMed Articles

 | Geisel Profile

ARTI GAUR, PH.D.

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Arti Gaur

Assistant Professor of Neurology

Office:  6th Floor of Rubin

Phone:  603-653-9940

Dr. Gaur's laboratory research can be broadly divided into the following three areas:

Basic Research: Understanding the critical contribution of microRNAs and their targets to various pathologies of the nervous system.

Translational Research: Running clinical trials to establish the role of microRNAs as diagnostic and prognostic biomarkers and therapeutic agents in gliomas as well as biomarkers of treatment efficacy and toxicity in glioma patients.

Biomedical Engineering: Developing innovative, in vivo wireless, nano scale devices for early detection of disease as well as regulated and targeted drug delivery.

Website   Email   PubMed Articles

 

Scott A. Gerber, Ph.D.

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Scott Gerber

Kenneth E. and Carol L. Weg Distinguished Professor of Molecular and Systems Biology, and Professor of Biochemistry and Cell Biology, Associate Director of QBS Program

Office: 734 Rubin

Phone: 603-653-3679 


Research in the Gerber Lab is focused on developing and using modernproteomics methods to understand the mechanisms by which dysregulated mitotic kinases, such as Aurora kinase A, contribute to the onset and maintenance of cancers.

Website | Email | PubMed Articles

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William R. Green, Ph.D.

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William Green

Elmer R. Pfefferkorn Professor of Microbiology and Immunology

Office: 603W Borwell

Phone: 603-646-5367


Our research focuses on the T-cell immune responses to retroviruses.


 

 

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Erik E. Griffin, Ph.D.

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Erik Griffin

Associate Professor of Biological Sciences

Office: 348 Life Sciences Center

Phone: 603-646-8269


We are interested in understanding how protein concentration gradients are generated in the cytoplasm and contribute to cell fate specification during development. We combine live imaging, biochemical and genetic approaches to study a series of cytoplasmic protein gradients that help pattern the early C. elegans embryo. 


Website | Email | PubMed Articles

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Gevorg Grigoryan, Ph.D.

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Gevorg Grigoryan

Associate Professor of Computer Science, and Biological Sciences

Office: Sudikoff 113

Phone: 603-646-3173


We are interested in understanding the design principles underlying natural protein function on a quantitative, structure-based level. We employ a mix of computational and experimental approaches to both understand functions of natural proteins and engineer proteins with novel functionality. 


Website | Email | PubMed Articles

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Karl E. Griswold, Ph.D.

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Karl Griswold

Associate Professor of Engineering, and Biological Sciences

Office: 128E Cummings Hall

Phone: 603-646-2127


The Griswold research group develops performance-enhanced biomolecules through the application of protein engineering technologies. Current projects are focused on biotherapeutic agents.


Website | Email | PubMed Articles

 | Faculty Profile

Mary Lou Guerinot, Ph.D.

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Mary Lou Guerinot

Ronald and Deborah Harris Professor in the Sciences, Professor of Biological Sciences, and Molecular and Systems Biology

Office: 325 Life Sciences Center

Phone: 603-646-2527


My principal expertise and research interests are in the area of metal transport and regulation of gene expression by metals. Plants are the major point of entry for essential metals into the food chain, so our work is laying the foundation for crops that offer sustainable solutions for malnutrition.


Website | Email | PubMed Articles | Faculty Profile

Allan Gulledge, Ph.D.

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Allan Gulledge

Associate Professor of Molecular and Systems Biology

Office: 601 Vail

Phone: 603-646-5249

Our research focus is the cerebral cortex, an area of the brain that serves as the biological substrate for the higher cognitive functions that define us as individuals. We wish to identify the mechanisms by which individual cortical neurons process and transmit information within the cortical circuit. To accomplish this we employ electrical and optical recording techniques that measure neuronal activity in neocortical neurons under a variety of experimental conditions.


Website | Email | PubMed Articles

 | Geisel Profile

Paul M. Guyre, Ph.D.

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Paul M. Guyre

Active Emeritus Professor of Microbiology and Immunology

Office: 646W Borwell

Phone: 603-646-5368

Dr. Guyre's principal research interests  to date have been: (i) Cancer immunotherapy; (ii) understanding the regulation and function of IgG Fc receptors on phagocytes, and (iii) how hormones and cytokines regulate the functional activity of white blood cells including monocytes, macrophages, dendritic cells, and neutrophils. The Guyre lab team is currently focused on finding biomarkers for the neuroimmune related disease, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and the tick-induced mammalian meat allergy Alpha Gal Syndrome. Vastly underdiagnosed, IgE anti-alpha gal (a sugar found on all mammals except humans) can induce life threatening anaphylaxis to not only meals of beef and pork, but to medications contained in gelatin capsules.

Email 

| Geisel Profile

Marnie E. Halpern, Ph.D.

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Marnie Halpern

Professor and Chair, Molecular and Systems Biology

Andrew Thomson, Jr., MD 1946 Professor

Office:   725A Remsen

Phone:   603-646-5251

The Halpern lab uses the zebrafish model to examine how left-right differences in the vertebrate brain arise and their functional significance. Using genetic, genomic, transgenic and optogenetic methods, they aim to map, manipulate, and monitor activity of neural pathways to understand their influence on behavior.

Email | PubMed Articles  | Geisel Profile

MATTHEW C. HAVRDA, Ph.D.

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Matthew Havrda

Assistant Professor of Molecular and Systems Biology

Office:   751 Rubin

Phone:   653-9933

Dr. Havrda lab is interested in characterizing neurodegenerative and neoplastic disorders of the central nervous system. Work in the laboratory is focused on two main themes: The characterization of inflammasomes and pyroptotic processes impacting the health of the aging brain and the study of how the neuronal microenvironment impacts the initiation and progress of gliomas in adults and children.

Email | PubMed Articles  | Geisel Profile

Bing He, Ph.D.

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Bing He

Assistant Professor of Biological Sciences

Office: 350 Life Sciences Center

Phone: 603-646-2649 


I am interested in how complex tissue and organ structures arise from simple tissue primordia. Using an interdisciplinary approach combining genetics, cell biology, biophysics and mathematical modeling, we seek to understand how developmental patterning information controls individual cell shape changes and how they are integrated into stereotyped tissue-scale deformations.


Website | Email 

| Faculty Profile

Henry N. Higgs, Ph.D.

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Henry Higgs

Professor of Biochemistry and Cell Biology, John La Porte Given Professor in Cytology

Office: 403 Vail

Phone: 603-646-5193

Mammalian cells use actin filaments in a huge number of ways, and we are trying to figure out how cells control when and where specific actin-based structures are made. We use a combination of cellular (live-cell microscopy, fluorescence microscopy, EM, cell-free assays) and biochemical (actin polymerization kinetics, analytical ultracentrifugation, structural analysis) in our research.


Website | Email | PubMed Articles

 | Geisel Profile

Robert A. Hill Ph.D.

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Robert Hill

Assistant Professor of Biological Sciences

Office:  344 Life Sciences Center

Phone:  603-646-6428

We study the multicellular interactions between neurons and glia in the brain with a primary focus on the development, plasticity, and regeneration of myelinating oligodendrocytes. Techniques include high-resolution optical imaging in combination with molecular labels, genetic manipulation, and sensors of cellular physiology.

WebsiteEmailPubMed Articles

 | Faculty Profile

Anne G. Hoen, Ph.D., M.Phil.

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Anne Hoen

Assistant Professor of Epidemiology, Biomedical Data Science, and Microbiology and Immunology

Office: 888 Rubin

Phone: 603-653-6087


Our work is on the development of the microbiome in infants and children, and the associations between environmental and dietary exposures, the microbiome, and risk for infectious diseases and other health outcomes.


Website | Email | PubMed Articles

 | Geisel Profile

Deborah A. Hogan, Ph.D.

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Deborah Hogan

Professor of Microbiology and Immunology

Office: 208 Vail

Phone: 603-646-5371

We study the mechanisms by which bacterial and fungal pathogens regulate virulence determinants within multicellular populations, within microbial communities and in the context of mammalian hosts.


 

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Michael B. Hoppa, Ph.D.

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Michael Hoppa

Associate Professor of Biological Sciences, Co-Director of Integrative Neuroscience at Dartmouth Graduate Program

Office: 345 Life Sciences

Phone: 603-646-8850


We explore the molecular mechanisms that control ion channel localization, expression and function in primary neurons using quantitative optical approaches in combination with genetic and biochemical tools. 


 

Website | Email | PubMed Articles | Faculty Profile

Yina H. Huang, Ph.D.

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Yina Huang

Associate Professor of Microbiology and Immunology, and Pathology and Lab Medicine, Vice-Chair of the MCB Program

Office: 604E Borwell

Phone: 603-646-5373

We investigate how T cells traffic and respond to infections and tumors. In particular, we study the signals that regulate differentiation and migration of effector and memory T cell and are exploring methods to manipulate their activity to ensure protective and durable immune protection. 


Website | Email | PubMed Articles

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Thomas P. Jack, Ph.D.

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Thomas P. Jack

Professor and Chair of Biological Sciences

Office: 331 Life Sciences Center

Phone: 603-646-3367


Molecular Genetics of flower development in Arabidopsis thaliana.


Website | Email | PubMed Articles

 | Faculty Profile

 

 

Claudia Jakubzick, Ph.D.

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Claudia Jakubzick

Associate Professor of Microbiology and Immunology

Office:  628W Borwell

Phone:  603-646-5376

My lab primarily focuses on understanding the functional role of mononuclear phagocytes (i.e., macrophages, monocytes, and dendritic cells) in homeostasis and inflammation. Current projects include 1- The regulation of the adaptive immune response by dendritic cells and monocytes, 2- The role of interstitial macrophages during inflammation, 3- The role of B cells and mononuclear phagocytes in transplant rejection and early-stage cancer recognition, and 4- Defining the human and mouse mononuclear phagocyte counterparts in the lung, skin and draining lymph nodes.

Email

 

 

Dionna M. Kasper

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Kasper
Dionna M. Kasper, Ph.D.

Assistant Professor of Molecular and Systems Biology

Office:  706A Remsen

Phone:   603-646-5254

Brief research description:

The Kasper lab investigates how vascular endothelial cells adopt alternate cell fates to become hematopoietic stem cells or lymphatic progenitors. We use a combination of live imaging, genetic and biochemical approaches, and high-throughput 'omic' technologies in the zebrafish embryo to dissect how epigenetic to posttranslational gene regulatory mechanisms control these important developmental decisions.

Email / PubMed

 

Arminja N. Kettenbach, Ph.D.

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Arminja Kettenbach

Associate Professor of Biochemistry and Cell Biology

Office: 763 Rubin 
Phone: 603-653-9067 


Research in the lab focuses on understanding the molecular mechanisms by which phosphatases contribute to phosphorylation-dependent signal transduction in mitosis. We use cell biological, biochemical, and proteomics approaches to decipher the connectivity and complexity of these signaling events in normal and cancer cells. 


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F. Jon Kull, Ph.D.

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F. Jon Kull

Rodgers Professor of Chemistry, and Biochemistry and Cell Biology

Dean, Guarini School of Graduate and Advanced Sciences

Office: 304 Burke

Phone: 603-646-1552 


Our laboratory uses biophysical techniques to study protein structure and function. Our goal is to understand at a fundamental level the conformational changes that occur in proteins as they complete the various cellular functions. 


Email | Faculty Profile

BONNIE W. LAU, M.D., PH.D.

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Bonnie Lau

Assistant Professor of Pediatrics, NCCC

Office:  606 Rubin

Phone:  603-650-5541

 

The Lau Laboratory investigates pathways that can be modulated to prevent malignant transformation or treat cancers that arise in patients with cancer predisposition syndromes. One focus of the lab is to study premalignant and malignant tissue from patients with DNA damage repair defects  (e.g. Fanconi Anemia) and determine whether the mutations in these patients result in new protein coding sequences, called neoantigens, which can be recognized as "foreign" by the patient's immune system.  Certain neoantigen profiles can predict response to therapies that work by unleashing the patient's own immune system to attack their tumor (immunotherapies).  We are using gene editing as well as mouse models to study these cancer predisposition syndromes and how their tumors respond to immunotherapies.

Website   Email   Geisel Profile  PubMed Articles

Steven D. Leach, M.D.

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Steven Leach

Director of Norris Cotton Cancer Center

Preston T. and Virginia R. Kelsey Distinguished Chair in Cancer

Professor of Molecular and Systems Biology

Office: DH, Rubin Building, Room 801

Phone: 603-653-3611 


The Leach lab studies pancreatic developmental, epithelial and tumor biology, using mouse, zebrafish and human model sytems. 


Email | PubMed Articles

 | Geisel Profile

Jiwon Lee, Ph.D.

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Jiwon Lee

Ralph and Marjorie Crump Assistant Professor of Engineering

Thayer School of Engineering

Office:  751 Williamson Translational Research Building

Phone:  603-646-3485

The Lee Lab studies the dynamics of antibody repertoires in infectious disease, autoimmune disease, and cancer using high-throughput sequencing of B cell transcripts and high-resolution mass spectrometry. The repertoire of antibody molecules circulating in blood or coating mucosal surfaces is the basis for protective immunity, and we employ machine learning frameworks, big data analytics tools, proteomic analytical methods, and data modeling to gain clinically relevant insights regarding protective mechanisms at unprecedented details. Leveraging this knowledge, we aim to design next-generation therapeutics and vaccines precisely tailored to maximize effectiveness in the context of particular diseases and/or patients (i.e.personalized/precision medicine).

Website | Email | PubMed Articles 

Wei-Lih Lee, Ph.D.

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Wei-Lih Lee
Professor of Biological Sciences

Office: Class of 1978 Life Sciences Center, Room 224

Phone: 603-646-8706

I am interested in understanding how eukaryotic cells organize, position, and segregate their organelles during asymmetric cell divisions. We combine classical genetics and live-cell microscopy with biochemical and biophysical techniques to elucidate the molecular pathways that regulate the microtubule cytoskeleton and the motor proteins responsible for organellar interaction and positioning in our model system budding yeast.

Email | Faculty Profile

David A. Leib, Ph.D.

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David Leib

Professor and Chair of Microbiology and Immunology

Office: 630E Borwell

Phone: 603-646-5232

We study the molecular pathogenesis of herpes simplex virus (HSV). In particular, we are interested in ways that viruses evade both innate and adaptive immune responses.
We also study maternal immunity to HSV infections and how it shapes the pathogenesis of neonatal HSV – a rare yet devastating manifestation of HSV infection.

Website | Email | PubMed Articles

 | Geisel Profile

Jennifer J. Loros, Ph.D.

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Jennifer Loros

Professor of Biochemistry, and Molecular and Systems Biology

Office: 704 Remsen

Phone: 603-646-5247

Our laboratories are interested in the genetic and molecular dissection of circadian systems in eukaryotic cells with a research emphasis on the fungus Neurospora and mammalian tissue culture. The circadian system comprises the core molecular feedback loop, how this loop feeds information to the cell and organism and how input to the loop via temperature changes and photoreceptors is regulated.


Website | Email | PubMed Articles

 | Geisel Profile

Bryan W. Luikart, Ph.D.

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Bryan Luikart

Associate Professor of Molecular and Systems Biology

Office: 604 Vail

Phone: 603-646-5258

We are interested in how gene mutations that cause autism alter neuronal development and function. To study this we engineer viruses to perform in vivo genetic manipulations and employ electrophysiology and multi-photon microscopy to study the impact of genetic manipulations on neuronal function. 


 

Website | Email | PubMed Articles

 | Geisel Profile

Lee R. Lynd, D.E.

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Lee Lynd

Paul E. / Joan H. Queneau Distinguished Professor in Environmental Engineering Design, and Professor of Biological Sciences

Office: 128D Cummings

Phone: 603-646-2231 


Professor Lynd is an expert on the production of energy from plant biomass and conducts leading research on microbial cellulose utilization. 


Website | Email | PubMed Articles

 | Faculty Profile

Dean R. Madden, Ph.D.

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Dean Madden

Professor of Biochemistry and Cell Biology

Dartmouth Vice Provost for Research

Office: 408A Vail

Phone: 603-646-5197

Structure and function of ion channels and proteins that regulate their intracellular trafficking.


Website | Email | PubMed Articles

 | Geisel Profile

Robert A. Maue, Ph.D.

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Robert Maue

Professor of Medical Education, and Biochemistry and Cell Biology

Office: 210 Remsen

Phone: 603-650-1726

We are interested in understanding the mechanisms important for the development and differentiation of neurons in the brain. 


Email | PubMed Articles

 | Geisel Profile

C. Robertson McClung, Ph.D.

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C. Robertson McClung

Patricia F. / William B. Hale 1944 Professor in the Arts and Sciences, Professor of Biological Sciences

Office: 323 Life Sciences Center

Phone: 603-646-3940


The ability of an organism to measure time is the product of a cellular biological clock. Many phenomena controlled by the biological clock cycle on a daily basis and are called circadian rhythms. My goal is to understand the genetic and biochemical mechanisms by which a plant measures time and uses that temporal information to regulate gene expression and cellular physiology.


Website | Email | PubMed Articles

 | Faculty Profile

Aaron McKenna, Ph.D.

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Aaron McKenna

Aaron McKenna, Ph.D.

Assistant Professor of Molecular and Systems Biology

Office:  Williamson Translational Building, Room 658

Phone:  603-650-1866

My lab is interested in how cells grow and divide to form complex structures, such as the transformation from the zygote to an adult human or from a transformed cell into a tumor mass. To study these processes, we develop technologies to trace pattern of cell divisions which recovers the lineage of each cell. This information can be combined with other measures of cell state such as single-cell transcriptomic data to develop a rich picture of how choices are made in development and how this process is dysregulated in diseases such as cancer.

Website | Email | PubMed Articles

Dale F. Mierke, Ph.D.

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Dale Mierke

Professor of Chemistry, and Biochemistry and Cell Biology

Office: 202 Burke

Phone: 603-646-1154


Develop molecular inhibitors of specific protein-protein interactions which may find use as physiological tools or eventual therapeutic agents, using the structural features as determined from many experimental (mainly NMR) and computational techniques.


Email | PubMed Articles

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TODD W. MILLER, PH.D.

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Todd Miller

Associate Professor of Molecular and Systems Biology

Office:  604 Rubin

Phone:  603-653-9284

 

Research in the Miller Laboratory focuses on the identification of cancer signaling pathways and the development of targeted therapies for breast and other cancers. Our work spans the spectrum of basic cancer biology, through translational studies in mouse models and human tissues, and engages with Phase 1/2 clinical trials. We use an array of methods and technologies in these endeavors, including mammalian tissue culture, gene and protein expression and activation profiling, chromatin immunoprecipitation, massively parallel DNA sequencing, bioinformatics, mouse models, and live animal imaging.

 

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James B. Moseley, Ph.D.

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James Moseley

Professor of Biochemistry and Cell Biology

Office: 412 Remsen

Phone: 603-646-5202

Many cell types delay cell cycle transitions until they reach a critical size threshold. We are studying the cellular mechanisms that measure size, and their role in coordinating cell growth and division.

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Larry C. Myers, Ph.D.

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Lawrence Myers

Associate Professor of Medical Education, and Biochemistry and Cell Biology

Office: Vail 412

Phone: 603-650-1198

The goal of our lab is to determine how genetic and epigenetic information in eukaryotic cells is used to regulate the transcription of genes. We are particularly interested in how human fungal pathogens utilize epigenetic regulatory strategies to switch phenotypes and facilitate virulence.

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Carey D. Nadell, Ph.D.

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Carey D. Nadell

Assistant Professor of Biological Sciences

Office: 326 Life Sciences Center

Phone: 603-646-1019


Bacteria often live in groups, called biofilms, where they cooperate and compete using a broad spectrum of interactive behaviors. These interactions are central to how bacteria evolve, and how they cause disease. We use molecular genetics, confocal microscopy, computational simulations, and evolutionary analysis to understand the mechanisms and biofilm-scale consequences of bacterial cell-cell interaction.


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Randolph J. Noelle, Ph.D.

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Randolph Noelle

Thomas S. Kosasa Professor of Microbiology and Immunology

Office: 702 Rubin

Phone: 603-646-5378

We study mediators that control the development of adaptive immunity. Our current focus is on the role of retinoic acid in controlling immunity, elements of the immune microenvironment that control allograft tolerance and tumor immunity, and new members of the PD-L family that govern how monocytes regulate T cell responses.


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Josh Obar, Ph.D MCB'06

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Joshua Obar

Associate Professor of Microbiology and Immunology

Office: 650W Borwell

Phone: 603-646-5383

Research in the Obar lab investigates the mechanisms by which inflammatory leukocytes are recruited to the lungs during infections. Specifically, we are interested in viral infections, such as influenza A virus, and fungal infection, such as Aspergillus fumigatus. 


 

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George A. O'Toole, Ph.D.

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George O'Toole

Professor of Microbiology and Immunology

Office: 202 Remsen

Phone: 603-650-1248


My lab studies the molecular basis of biofilm formation on living and non-living surfaces, including the role of biofilms in disease. We also study host-pathogen interactions, and recently we have begun to explore the microbial communities associated with chronic lung infections, including cystic fibrosis.


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Diwakar Pattabiraman Ph.D.

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Diwakar Pattabiraman

Assistant Professor of Molecular and Systems Biology, and Norris Cotton Cancer Center

Office: Rubin 602

Phone: 603-653-9957 


Our research focuses on understanding the genetic, epigenetic, signaling and cell biological aspects of tumor progression and metastasis in carcinomas. We study the role of transitions in epithelial and mesenchymal states within carcinomas as a model of understanding intratumoral heterogeneity to develop novel ways of overcoming metastatic progression and therapy resistance.


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Patricia A. Pioli, Ph.D. MCB'01

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Patricia Pioli

Associate Professor of Microbiology and Immunology

Office: 644E Borwell Building

Phone: 603-646-5385

Research in our laboratory is focused on identifying the molecular mechanisms that regulate macrophage activation in the context of both autoimmunity and cancer. Taking advantage of macrophage plasticity, we then use this information to determine how macrophage activation can be altered for maximal therapeutic benefit.


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Ekaterina V. Pletneva, Ph.D.

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Ekaterina Pletneva

Associate Professor of Chemistry, and Biochemistry and Cell Biology

Office: 114 Burke

Phone: 603-546-2501

Our studies examine the interplay between protein dynamics and redox reactivity in signaling transformations and address fundamental problems in reaction mechanisms, coordination chemistry and biology.

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Michael J. Ragusa, Ph.D.

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Michael Ragusa

Assistant Professor of Chemistry, and Biochemistry and Cell Biology

Office: 221 Burke

Phone: 603-646-9066

Autophagy is a catabolic cellular process capable of degrading large cellular material including organelles and aggregates. We are interested in elucidating the molecular mechanisms of autophagy through a combination of X-ray crystallography, small angle X-ray scattering and biochemistry.

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William F.C. Rigby, M.D.

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William Rigby

Professor of Medicine, and Microbiology and Immunology

Office: 608W Borwell

Phone: 603-646-7912

Dr. Rigby is examining the changes that accompany clinical responses in patients with rheumatoid arthritis treated with biologics.


 

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PAUL J. ROBUSTELLI, PH.D.

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Paul Robustelli

Assistant Professor of Chemistry, and Biochemistry and Cell Biology

Office:  203 Burke

Phone:  603-646-2270

The Robustelli laboratory integrates computational methods with biophysical experiments to obtain atomic-level descriptions of the functional motions of biomolecules, with a particular interest in intrinsically disordered proteins.  We aim to use insights from atomistic molecular simulations to understand, predict and design binding interactions of dynamic of disordered proteins and to elucidate general principles governing molecular recognition in dynamic systems.  A current focus of our laboratory is understanding the thermodynamic driving forces of small molecule ligands binding to disordered protein sequences, with the goal of providing new avenues to therapeutic interventions in diseases associated with disordered protein dysfunction through the rational design of small molecule and biologic inhibitors.

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Pamela Rosato, Ph.D., MCB'15

 

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Pamela Rosato

Assistant Professor, Microbiology and Immunology

Office:  732 Rubin Building

Phone:

Our research focuses on understanding the function and regulation of virus-specific resident memory T cells (TRM). Using mouse and human tissue explant models, we seek to develop a foundational understanding of TRMbiology in distinct tissues to be able to contextualize the role of TRMin pathologic and protective settings. Our current focuses are on the functions of anti-viral TRMin the brain, repurposing virus-specific TRMas a brain tumor immunotherapy, and investigating the role of TRMwithin tumors during oncolytic viral therapy.

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Benjamin D. Ross, Ph.D.

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Benjamin Ross

Assistant Professor of Microbiology and Immunology

Office:  504A Vail Building

Phone:  603-650-1123

The bacteria resident in the human gastrointestinal tract (the gut microbiota) potently influence diverse aspects of human health, including immunity. However, the forces that govern the composition of the gut microbiota are poorly understood. Our work focuses on a mechanistic, ecological, and evolutionary understanding of how interbacterial interactions between members of the dominant Gram-negative bacteria in the gut, the Bacteroidales, modulate the composition of the microbiota. The Bacteroidales utilize a contact-dependent toxin-delivery system known as the type VI secretion system (T6SS) to kill neighboring cells. We study the impact of this pathway on the microbiota and how bacteria adapt to defend against T6SS-mediated antagonism, using a combination of bacterial genetics, biochemistry, metagenomics, and germ-free mouse models. We are also interested in understanding why Bacteroidales abundance is depleted in individuals with cystic fibrosis, with the goal of improving health through restoration of these bacteria.

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Kimberley Samkoe, Ph.D.

Kimberley Samkoe, Ph.D.

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Kimberley Samkoe

Associate Professor of Surgery, and Thayer School of Engineering

Office:   Borwell 536E

Phone:   650-7618

Brief research description: My research takes a biological-systems-engineering approach to medical imaging by studying how microscopic molecular information can be interpreted at a macro-scale. My current research interests involve quantitative assessment of in vivo protein expression and signaling using fluorescence molecular imaging. These methodologies have applications in cancer for improving tumor identification, surgical resection, and patient-specific therapeutic monitoring.

 

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Yolanda Sanchez, Ph.D.

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Yolanda Sanchez

Professor of Molecular and Systems Biology

Associate Director for Basic Sciences, Norris Cotton Cancer Center

Office:  Vail 501

Phone:  603-646-5260

Checkpoint signaling events triggered during the response to DNA damage or replication interference, how they regulate cell cycle progression, DNA repair and cell death.  The role of checkpoints in the etiology of cancer and as drug targets for therapeutic enhancers of genotoxic cancer drugs.

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Rahul Sarpeshkar, Ph.D.

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Rahul Sarpeshkar

Thomas E Kurtz Professor, Professor of Engineering, Microbiology and Immunology, Physics, Molecular and Systems Biology

Office: 507A Vail

Phone: 603-646-6821


Synthetic analog and digital biological circuits in electri-cigenic and other microbes; Applications of synthetic and systems biology to immunology, infectious disease, and cancer; Precision measurement, electronic circuit modeling, and feedback control of living cells at the fundamental limits set by physics.

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G. Eric Schaller, Ph.D.

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G. Eric Schaller

Professor of Biological Sciences

Office: 339 Life Sciences Center

Phone: 603-646-2525


Signal transduction by the plant hormones ethylene and cytokinin, and how these hormones act to control growth and development.


 

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Daniel Schultz, Ph.D.

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Daniel Schultz

Assistant Professor of Microbiology and Immunology

Office: 206 Vail

Phone: 603-646-5390

The Schultz lab develops quantitative approaches to study the emergence, operation and optimization of the gene networks that control cell responses in bacteria, with a focus on antibiotic resistance mechanisms. We combine mathematical modeling, bioinformatics, experimental evolution and microfluidics to analyze how the cell controls the expression of resistance genes during drug responses. We strive to guide innovation in clinical therapies by uncovering the selective pressures that shape the evolution of antibiotic resistance in natural environments.

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Charles L. Sentman, Ph.D.

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Charles Sentman

Professor of Microbiology and Immunology, Director for Synthetic Immunity

Office: 640W Borwell

Phone: 603-646-5390

My laboratory is interested in innate immunity and how it regulates adaptive immunity in response to cancer and infectious disease. We focus our work on NK cells and CD8 T cells, and we are using innate immune receptors as a means to develop therapeutics for cancer.


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Christopher J. Shoemaker, Ph.D.

 

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Christopher Shoemaker
Assistant Professor of Biochemistry and Cell Biology

Office: 302B Vail

Phone: 603-646-5209

We are interested in the molecular mechanisms governing mammalian autophagy. We take a multidisciplinary approach involving CRISPR-based genetic screening, flow cytometry, quantitative microscopy and biochemical analysis.

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Roger D. Sloboda, Ph.D.

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Rodger Sloboda

Ira Allen Eastman Professor Biological Sciences, Active Emeritus

Office: 222 Life Sciences Center

Phone: 603-646-2377


We study microtubule dependent particle motility inside cells using intraflagellar transport (IFT) in the biflagellate green alga, Chlamydomonas and the primary cilia of MDCK cells in culture as the model systems.


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Bruce Stanton, Ph.D.

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Bruce Stanton

Andrew C. Vail Memorial Professor

Professor of Microbiology and Immunology, and of Physiology

Office: 615 Remsen

Phone: 603-646-5395

Our laboratory studies the genetic disease Cystic Fibrosis. In particular we study host pathogen interactions between bacteria and human airway epithelial cells and the interactome of CFTR and how interacting proteins regulate CFTR trafficking. We also examine how environmental toxins, in particular arsenic, cause and contribute to respiratory and diseases and inflammation.


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Surachai Supattapone, M.D., Ph.D., D.Phil.

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Surachai Supattapone
Professor of Biochemistry and Cell Biology, and Medicine

Office: 311 Vail

Phone: 603-646-5212

Our lab investigates the molecular mechanisms responsible for the propagation of protein misfolding in neurodegenerative diseases, with special focus on infectious mammalian prions.  We also use whole genome CRISPR libraries to study various areas of cell biology in mammalian cells.

 

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Mary Jo Turk, Ph.D.

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Mary Jo Turk

O. Ross McIntyre, M.D. Endowed Professor of Microbiology and Immunology, Co-Director, Immunology and Cancer Immunotherapy Program

Office: 732 Rubin

Phone: 603-646-5397

Our research focuses on understanding how the immune system responds to cancer, with an emphasis on T cell memory. We are also interested in learning how autoimmunity influences anti-tumor immunity.

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Edward J. Usherwood, Ph.D.

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Edward Usherwood

Professor of Microbiology and Immunology

Office: 608E Borwell

Phone: 603-646-5224


Research in the Usherwood lab focuses on T cell-mediated immune surveillance to virus infections and cancer. We are interested in factors that regulate T cell memory and immune surveillance. A major goal is to exploit these findings to develop novel immunotherapies for cancer and persistent virus infections.

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Xiaofeng Wang, Ph.D.

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Xiaofeng Wang

Assistant Professor of Molecular and Systems Biology

Office: 632 Rubin

Phone:  603-653-9974


Our work focuses on cancer epigenetics. We are particularly interested in studying a family of chromatin remodeling complexes, which are frequently mutated in a variety of human cancers. Our work is aimed to understand how these mutations cause cancer, focusing on the regulation of chromatin structure dynamics (epigenomics) and chromatin remodeler protein complex assembly, as well as using genetic and chemical screens to identify potential therapeutic targets in human cancers. 


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Michael L. Whitfield, Ph.D.

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Michael Whitfield

Professor of Molecular and Systems Biology

Chair of Biomedical Data Sciences

Office: 705A Remsen

Phone: 603-650-1105 


The complexities of biological systems can now be studied with genome-wide approaches that take a global view of the underlaying biology. 


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William T. Wickner, M.D.

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William Wickner

Professor of Biochemistry and Cell Biology

Office: 425 Remsen

Phone: 603-646-5214

We study how membrane vesicles fuse as they deliver new proteins, hormones, and neurotransmitters to their destinations.

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Hermes Yeh, Ph.D.

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Hermes Yeh

William W. Brown 1835 Memorial Professor

Professor of Molecular and Systems Biology, and Neurobiology

Office: 625 Remsen

Phone: 603-646-5264

My lab is interested in the cellular and molecular mechanisms of neurotransmitter and neuroreceptor interactions in the adult and developing brain. Ongoing research combines neuroanatomical, electrophysiological, molecular and behavioral approaches in a mouse model of FASD to study the consequences of prenatal ethanol exposure on embryonic corticogenesis, neurotransmitter receptors, synaptic transmission, and behavior. Our work has unifying implications insofar as the insights gained may be applicable toward understanding the pathoetiology of other neurodevelopmental brain disorders, such as autism and ADHD.

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Olga Zhaxybayeva, Ph.D.

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Olga Zhaxybayeva

Associate Professor of Biological Sciences

Office: 333 Life Sciences Center

Phone: 603-646-8616


My lab's research focus is to better understand evolution of microbes through computational analyses of genomic and metagenomic data.


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